The FDA Just Approved a New Prescription Weight-Loss Drug. Here ’s How It Works

In a rare move, the Food and Drug Administration (FDA) has approved a novel prescription drug meant to help with weight loss and weight management. The drug, called Plenity and developed by Gelesis, has been cleared for overweight or obese adults with a body mass index of at least 25, even if they do not have other health problems. It should be used in conjunction with diet and exercise, the FDA says, and can also be taken alongside other weight-loss medications. That sweeping approval is noteworthy, says Dr. Caroline Apovian, who has studied Plenity in Gelesis-sponsored research and is the director of nutrition and weight management at Boston Medical Center, because most weight-loss treatments are available only to patients with a BMI of 30 or above, or who have other weight-related health issues. “Right now, between a BMI of 25 and 30 we have a big treatment gap. If you’re overweight and you have no [other issues]…all we have to offer is lifestyle,” Apovian says. “Now, there is a treatment.” It has traditionally been difficult to find science-backed, non-surgical weight-loss aids that work. Aside from Plenity, the FDA has approved only five prescription weight-loss drugs, and has repeatedly warned consumers against taking products claiming they can cause weight-loss “miracles.” Over-the-counter dietary supplements promising weight loss — which are not regulated by the FDA — also tend to be ineffective at best, an...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news

Related Links:

This study was carried out in strict accordance with recommendations of the National Institutes of Health guide for the care and use of Laboratory animals. Before undergoing the experimental work, the protocol was approved by the Comité Institutionnel de Protection des Animaux (CIPA) of UQAM (Permit Number: 0515-R3–759-0516). After a 3-day acclimatization period at UQAM’s animal facility, young (100–125 g; approximately 4 weeks old) male Wistar rats (Charles River, St-Constant, QC, Canada) were randomly fed with a regular chow diet (RCD; n = 13) or HFD (n = 12) for 14&...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract The discovery of "oestrus-producing" hormones was a major research breakthrough in biochemistry and pharmacology during the early part of the 20th century. The elucidation of the molecular weight and chemical structure of major oxidative metabolites of dehydroepiandrosterone (DHEA) led to the award of the Nobel Prize in 1939 to Adolf Frederick Johann Butenandt and Leopold Ruzicka. Considered a bulk androgen in the circulation, DHEA and its sulfated metabolite DHEA-S can be taken up by most tissues where the sterols are metabolized to active androgenic and estrogenic compounds needed for growth a...
Source: Vitamins and Hormones - Category: Endocrinology Authors: Tags: Vitam Horm Source Type: research
Conclusions: Self-monitoring is a promising approach to weight management for overweight and obese pregnant women. However, healthcare providers should be aware that, although women may identify several benefits to self-monitoring, for some women, consistently trying to track their behaviors is stressful.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
AimTo determine factors associated with a serious outcome (hospital admission or severe outcome: critical care or death) and associated with illness caused by laboratory‐confirmed influenza, with a specific interest in low‐ and middle‐income countries (LMIC). MethodDatabases were searched on 11 March 2016 for reports of influenza and factors associated with mortality or morbidity in humans, with no language restrictions. Pooled risks were estimated using random‐effects models. ResultsDespite the heterogeneity of results across studies, known risk factors for serious disease were associated with both hospital admiss...
Source: Influenza and Other Respiratory Viruses - Category: Virology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractStone surgery is one of oldest surgical practices undertaken by man. Hippocrates refused to let his followers “cut for the stone” and it was only in February 1980, when the first human trial of shock wave therapy on a renal stone was performed with success that a new era in minimally invasive treatment (surgery) for stones was opened up and this condemnation was finally resolved in the Hippocratic Oath. Endoscopy, using natural orifices, supported by anaesthesia, incremented by technology and with access to all points along the urinary tract, began by competing with ESWL, but is now the treatment of cho...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
Conclusion: We think that exposures to hazardous substances migrating from FCAs require more attention. We recommend a) limiting the number and types of chemicals authorized for manufacture and b) developing novel approaches for assessing the safety of chemicals in FCAs, including unidentified chemicals that form during or after production. https://doi.org/10.1289/EHP644 Received: 10 June 2016 Revised: 08 June 2017 Accepted: 09 June 2017 Published: 11 September 2017 Address correspondence to J. Muncke, Food Packaging Forum, Staffelstrasse 8, 8045 Zurich, Switzerland. Telephone: 41-44-5155255. Email: jane.muncke@fp-fo...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Conclusion: Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed. Overall, the underlying mechanisms described a broader impact beyond BPA exposure and can be applied to understand other models of NAFLD. https://doi.org/10.1289/EHP664 Received: 15 June 2016 Revised: 28 January 2017 Accepted: 31 January 2017 Published: 04 August 2017 Address correspondence to A.L. Slitt, Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Gre...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
By DAVID INTROCASO THCB readers are well aware this coming week Senate Republicans plan to begin debate on passing their amended version of the House-passed American Health Care Act (AHCA), titled the Better Care Reconciliation Act.   As of today, June 23rd, immediate reactions by Republican senators to the June 22nd released discussion draft have been limited largely because members immediately left town after the draft’s release. The Congressional Budget Office’s (CBO’s) score, that will again be influential, is expected this Monday or Tuesday. Senate debate on the legislation will likely begi...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized AHCA CBO David Introcaso Repeal Replace Senate Republicans Source Type: blogs
More News: Allergy & Immunology | Brain | Complementary Medicine | Diets | Eating Disorders & Weight Management | Food and Drug Administration (FDA) | Gastroenterology | Health | HIV AIDS | Insurance | Neurology | Nutrition | Obesity | Pregnancy | Primary Care | Profits and Losses | Science | Sports Medicine | Study | Weight Loss | Women