New cancer therapies offer great hope, but there can be surprising complications

An oncologist says the pace of change in treatment has been staggering, but for many patients, chemo is still right.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

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Double ‐faced (Janus) gold‐iron oxide nanoparticles combine magnetic and plasmonic features as smart multifunctional platforms for theranostics nanomedicine. Herein, they are proved as efficient therapeutic nanoheaters under both magnetic hyperthermia (MHT) and photothermia (PTT) procedures. Thanks to the magnetic core, PTT can be improved on‐site upon systemic administration and magnetic guiding, leading to tumor growth inhibition. AbstractProgress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Yolk –shell structured eccentric mesoporous organosilica nanocomposites with adjustable mechanical property are successfully prepared, which provides an ideal and universal mesoporous nanoplatform for further experimental investigations of bio–nano interactions and potential applications of high‐ef ficiency cancer therapy. AbstractMesoporous nanoparticles as a versatile platform for cancer theranostics have been widely used, but their cellular delivery efficiency is still far from satisfactory. Although deformability is emerging as an important parameter influencing cellular uptake enhancement, the facile syn...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Iodine ‐rich semiconducting polymer nanoparticles (SPN‐I) are designed and prepared. Because of its high iodine density and the presence of fluorescent semiconducting polymer PCPDTBT, SPN‐I can be applied for fluorescence/computed tomography dual‐modal imaging. In addition, the efficacy of photodyn amic therapy for SPN‐I is enhanced by virtue of the intermolecular heavy‐atom effect induced by iodine. AbstractPhotodynamic therapy (PDT) is a promising technique for cancer therapy, providing good therapeutic efficacy with minimized side effect. However, the lack of oxygen supply in the hypoxic tumor site obviously...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
The synthesis and functionalization of metal –organic frameworks (MOFs) for biomedical applications in the delivery of cargos (drugs, nucleic acids, proteins, and dyes) for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis are overviewed, and the development prospects and challenges of MOF‐based theranostic systems ar e also discussed. AbstractMetal –organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during...
Source: Small - Category: Nanotechnology Authors: Tags: Review Source Type: research
This study paves the way for the future use of not only g ‐C3N4 but also other 2D nanomaterials in cancer therapy.
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Publication date: 15 June 2020Source: Chemical Engineering Journal, Volume 390Author(s): Guozhu Tan, Yingtao Zhong, Linlin Yang, Yaodong Jiang, Jianqiang Liu, Fei Ren
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Prostate cancer therapies are improving over time. But how do the long-term side effects from the various options available today compare? Results from a newly published study are providing some valuable insights. Investigators at Vanderbilt University and the University of Texas MD Anderson Cancer Center spent five years tracking the sexual, bowel, urinary, and hormonal status of nearly 2,000 men after they had been treated for prostate cancer, or monitored with active surveillance (which entails checking the tumor periodically and treating it only if it begins to grow). Cancers in all the men were still confined to the p...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
AbstractAimsChildhood cancer therapy is associated with a significant risk of therapy ‐related cardiotoxicity. This meta‐analysis aims to evaluate cardiac biomarkers for the detection of cancer therapy‐related left ventricular (LV) dysfunction in childhood cancer patients.Methods and resultsPubMed, Cochrane Library, Wiley Library, and Web of Science were screened for studies investigating brain natriuretic peptide (BNP)/N ‐terminal proBNP (NT‐proBNP) or cardiac troponin in childhood cancer patients. The odds ratios (OR) for elevation of cardiac biomarkers and association with LV dysfunction were calculated using ...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Publication date: Available online 26 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Lukas Gorecki, Martin Andrs, Martina Rezacova, Jan Korabecny
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionOur results demonstrate that various currently FDA-approved drugs might be candidates for targeted therapy of GC. For clinical trials, cancer patients should be selected based on the genomic profile of their tumor.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
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