U.S. Supreme Court rejects Allergan bid to use tribe to shield drug patents
The U.S. Supreme Court on Monday cast aside pharmaceutical company Allergan Plc's unorthodox bid to shield patents from a federal administrative court's review by transferring them to a Native American tribe.
Conclusion: These results contrast with previous reports of exacerbated AAD in SCD mice exposed to OVA and support the alternative hypothesis that asthmatic responses are normal in those with SCD.Int Arch Allergy Immunol
Conclusions: In asthma and allergy, multimorbidity and polypharmacy are major concerns. Disease severity, drug use, and costs increased with multimorbid conditions. To reduce the burden, allergy management should be better integrated and more comprehensive.Int Arch Allergy Immunol
Researchers used an experimental gene therapy to develop a possible treatment for a rare and deadly immune disorder known as “bubble boy” disease, the National Institutes of Health (NIH) announced Wednesday. Because of a gene mutation, babies who are born with X-linked severe combined immunodeficiency (X-SCID) do not develop immune cells properly, leaving them highly susceptible to infections. The condition, which strikes up to one in 50,000 newborns, primarily affects boys and requires extreme measures to prevent infection. In one famous case, a boy with SCID, David Vetter, lived in a sterile plastic “bu...
THURSDAY, April 18, 2019 -- You might be surprised to learn that food allergies can start in adulthood and involve a food you've eaten without a problem for your entire life. For adults as well as kids, the top -- but not the only -- food culprits...
(NIH/National Institute of Allergy and Infectious Diseases) In 2000, measles was declared to be eliminated in the United States. Today, the US and many other countries are experiencing outbreaks of measles because of declines in measles vaccine coverage. Without renewed focus on vaccination efforts, the disease may rebound in full force, according to a commentary in NEJM by infectious diseases experts at the National Institute of Allergy and Infectious Diseases and Penn State University College of Medicine's Milton S. Hershey Medical Center.
(NIH/National Institute of Allergy and Infectious Diseases) Antiretroviral therapy (ART) is usually effective at suppressing HIV, allowing the immune system to recover by preventing the virus from destroying CD4+ T cells. Scientists have now identified a rare, paradoxical response to ART called extreme immune decline, or EXID. Five individuals evaluated at the NIAID experienced a significant decline in CD4+ T cell levels despite suppression of HIV below detectable levels for more than three years, according to a report published in JCI Insight.
Healthy and uncomplicated lupus pregnancies have similar immune signatures that differ from those in complicated lupus pregnancies, researchers report.Reuters Health Information
Publication date: Available online 17 April 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lorcan McGarvey, Peter G. GibsonAbstractTerminology used to define clinical cough is based on features such as duration, underlying causes and associated characteristics such as whether the cough is ‘dry’ or ‘productive’. Terms such as ‘Refractory Chronic Cough’, ‘Unexplained Chronic Cough’ and ‘Idiopathic Cough’ are commonly used to describe a cough that persists despite extensive investigation and therapeutic trials. The use of these term...
ConclusionsWe are the first group to describe preschool P-OIT in a real-world multicenter setting. The treatment appears to be safe for the vast majority of patients because symptoms were generally mild and very few reactions received epinephrine; however, life-threatening reactions in a minority of patients (0.4%) can still occur.