Boy's 'lazy eye' turns out to be a sign of a terminal brain tumour

Tony and Soeli Stephenson, of Norfolk, thought their son, Charlie, nine, just needed glasses. But their life 'crumbled' after tests revealed an inoperable tumour in February.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

Related Links:

Conclusion Several TISC-based immunotherapeutic approaches are under development in various stages of preclinical studies. As outlined in this review article, a careful and more exhaustive genetic and metabolic understanding of TISC-associated phenotypes is critical to develop novel TISC based immunotherapies. Various components within the tumor microenvironment such as tumor cells, infiltrating immune cells, and supporting stromal cells impact the TISC metabolism. This unique metabolic profile leads to upregulation of certain enzymes and proteins such as ALDH1, CEP55, IDO COA1 etc., which can be utilized for development ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children’s Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radi...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Publication date: 23 April 2019Source: Cell Reports, Volume 27, Issue 4Author(s): Emily Wingrove, Zongzhi Z. Liu, Kiran D. Patel, Anna Arnal-Estapé, Wesley L. Cai, Mary-Ann Melnick, Katerina Politi, Cátia Monteiro, Lucía Zhu, Manuel Valiente, Harriet M. Kluger, Veronica L. Chiang, Don X. NguyenSummaryThe brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-seque...
Source: Cell Reports - Category: Cytology Source Type: research
Conditions:   High Grade Glioma;   Brain Cancer Intervention:   Drug: Nivolumab Sponsors:   Assistance Publique - Hôpitaux de Paris;   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
hlberg K Abstract OBJECTIVES: To explore symptom clusters during proton beam therapy in patients with primary brain tumors and investigate associations among symptom clusters, demographic variables, and comorbidity in this patient population. SAMPLE & SETTING: Data were collected from 187 adult patients with primary brain tumors during their treatment periods in the Skandion Clinic in Uppsala, Sweden. Symptoms were assessed with the Radiotherapy-Related Symptoms Assessment Scale, and comorbidity was evaluated with the Self-Administered Comorbidity Questionnaire. METHODS & VARIABLES: The study use...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
Publication date: Available online 22 April 2019Source: Materials Science and Engineering: CAuthor(s): Yung-Chih Kuo, Li-Jung Wang, Rajendiran RajeshAbstractThe use of chemotherapy against brain tumors faces various limitations to achieving its therapeutic effect, due to both the inability of anticancer agents to cross the blood–brain barrier (BBB) and the formation of brain cancer stem cells (BCSCs). Without adequate exposure, these chemotherapeutic drugs cannot have an antiproliferative effect on the tumors. Here, we developed curcumin (CCM)-loaded chitosan-poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) m...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this work, we evaluated incidence, mortality, prevalence, and relative survival for patients with grade III gliomas during 2000 ‐2013. We also investigated risk factors for prognosis and integrated these risk factors to construct a nomogram to predict the survival for patients with these tumors. We concluded that the incidence was stable and the mortality rate declined significantly during 2000‐2013, as well as older age , black race, male, divorced status, nonfrontal location, histology of AA, smaller tumor size and no surgical resection were associated with worse survival. AbstractBackgroundPopulation ‐based stu...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Comparative analysis of the effects of chemically transformed polyene antibiotics pimaricin, nystatin, lucensomycin, amphotericin B, and levorin on biological objectsin vivo andin vitro revealed the greatest biological activity of original amphotericin B and levorin with its derivatives. The study also examined the effects of alkyl derivatives of amphotericin B and levorin modified in certain parts of the lactone ring on the lipid and biological membranes. It is established that methylated levorin possesses larger biological activity than the original antibiotic. Examination of the effects of alkyl derivatives of levorin a...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
In conclusion, while rs-fMRI use in clinical neuroradiology practice is limited, enthusiasm appears to be quite high and there are several possible avenues in which further research and development may facilitate its penetration into clinical practice. Introduction Techniques for quantifying spatial and temporal brain activity have developed rapidly since the first demonstrations that MRI could be used to measure modulations in blood oxygen level dependent (BOLD) tissue contrast (1). The observation that MRI could be used to monitor temporally correlated low-frequency activity fluctuations in spatially remote brain a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: This study demonstrated a rapid improvement of many symptoms in the subacute post-operative period in pituitary tumor patients. Disturbed sleep was identified as the only symptom to worsen post-operatively, encouraging potential prospective interventions to improve sleep, and subsequently improve the QOL in pituitary tumor patients following surgical intervention. Introduction Pituitary tumors are relatively rare primary central nervous system (CNS) tumors in adults (1) but make up 10% of all neurosurgical interventions in the United States (2). They are often an incidental finding in autopsies and brain...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Brain | Brain Tumor | Health | Neurology