Five-minute ‘spot the animal’ iPad test could detect signs of dementia

The South London and Maudsley NHS trust is trialling an online test designed to spot early signs of dementia by seeing how quickly and accurately people can identify photos of animals.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Śmigórska A, Śmigórski K, Rymaszewska J Abstract The following article discusses the possibility of applying a rehabilitation strategy known as Errorless Learning (EL) in patients suffering from Alzheimer's disease (AD). The authors present the issue in the context of the knowledge on the effectiveness of administering neuropsychological interventions in patients with AD. The history of the EL method development is presented as well as techniques used in its domain. The novelty of the EL methodological approach is shown. It is emphasized that EL, in contrast with the majority of neuropsycho...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: These results are especially relevant when compared to previous SSD studies showing effects in behavior only after a demanding cognitive training. We discuss the implications of our results for development of SSDs and of specific rehabilitation programs for the hearing impaired either using or not using HAs or CIs. We also discuss the potential application of such a set-up for sense augmentation, such as when learning a new language. PMID: 31006700 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Conditions:   Mild Cognitive Impairment;   Alzheimer Dementia Intervention:   Behavioral: Supervised Exercise Programme Sponsors:   University of Cadiz;   Centro de Excelencia en Metabolómica y Bioanálisis (CEMBIO);   Servicio Central de Neuroimagen de la Universidad Pablo de Olavide;   Consejería de Salud y Bienestar Social, Andalucía Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 23 April 2019Source: Alzheimer's &DementiaAuthor(s): Mélanie Fortier, Christian-Alexandre Castellano, Etienne Croteau, Francis Langlois, Christian Bocti, Valérie St-Pierre, Camille Vandenberghe, Michaël Bernier, Maggie Roy, Maxime Descoteaux, Kevin Whittingstall, Martin Lepage, Éric E. Turcotte, Tamas Fulop, Stephen C. CunnaneAbstractIntroductionUnlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Researchers here report on discovering that an existing farnesyltransferase inhibitor drug reverses the accumulation of altered tau protein aggregates in a mouse model. The death and dysfunction of nerve cells in the neurodegenerative conditions known as tauopathies is driven by the formation of neurofibrillary tangles, made of tau protein. That in turn has deeper causes, such as the chronic inflammation produced by senescent cells and disruption of immune cell activity in the central nervous system, one of which is no doubt being adjusted in some way by the action of the drug in this case. As in all such quite indirect me...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
While clearing out amyloid-β from the brain has so far proven to be a matter of too little, too late in late stage Alzheimer's disease patients, there is still a strong basis of evidence for the merits of removing amyloid-β. It is reasonable to say that it causes meaningful pathology; if people did not accumulate amyloid-β deposits, then there would be no consequent disarray in the function of neurons and immune cells in the brain. This particular foundation of the development of dementia would be removed. Even if the mechanisms of the later stages of Alzheimer's, the chronic inflammation and tau protein agg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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