Sleep, oscillations, interictal discharges, and seizures in human focal epilepsy.

This article discusses the influence of sleep on adult focal epilepsy as assessed objectively via EEG, and highlights new developments of the last decade regarding sleep microstructure and new markers of the epileptogenic zone such as high-frequency oscillations >80 Hz. It further describes evidence obtained from invasive intracranial EEG, as this is a unique measure to assess directly cortical activity of superficial and deep structures of the human brain. Important achievements of the last decade were to unravel how epileptic activity is modulated by sleep, underlining the role of sleep slow waves to enhance epileptic activity, to demonstrate that seizure types are differently affected by sleep, and to show that sleep may be useful to better identify the epileptogenic zone for epilepsy surgery in drug-resistant epilepsy. PMID: 30981828 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research