Very early and early systemic sclerosis: An update.
[Very early and early systemic sclerosis: An update]. Rev Med Interne. 2019 Apr 10;: Authors: Michaud M, Catros F, Ancellin S, Gaches F Abstract Classification criteria for systemic sclerosis evolved over the last three decades, allowing an earlier classification. In the late 2000s, the EULAR Scleroderma Trials and Research Group validated very early and early systemic sclerosis criteria. Raynaud phenomenon, anti-nuclear antibody positivity and the puffy fingers are "Red flags" that must lead to refer the patient to a specialist and benefit from a capillaroscopy and the specific autoantibodies. At the stage of very early systemic sclerosis, pulmonary, cardiac and digestive involvements may be present and must be screened. Herein, we detail very early and early systemic sclerosis criteria, as well as the predictive factors of evolution towards a systemic sclerosis. PMID: 30981561 [PubMed - as supplied by publisher]
Systemic sclerosis (SSc) is a connective tissue disorder characterized by the development of fibrosis in the skin and internal organs, as well as microvascular dysfunction [1,2]. Vasculopathy occurs at an early step of SSc. Almost all patients present Raynaud's phenomenon as an initial symptom, and frequently show other manifestations of vascular diseases, including ischemic digital ulcers, pulmonary arterial hypertension, and renal arterial involvement associated with malignant hypertension and renal failure.
AbstractRaynaud ’s phenomenon (RP) is used to describe a symptom complex caused by digital vascular compromise. RP is a clinical diagnosis. The typically episodic nature of RP has resulted in a reliance upon patient self-report for diagnosis. The term ‘primary RP’ is generally applied when no underlying patho logy can be demonstrated. Whilst ‘primary RP’ is currently considered a distinct disorder, there is evidence that the term may comprise several entities that include a functional vasospastic disorder, a physiologically appropriate thermoregulatory response, subclinical atherosclerosis and...
Condition: Raynaud's Phenomenon Secondary to Systemic Sclerosis Interventions: Drug: Placebo IV infusion; Drug: Iloprost Injection, for intravenous use Sponsor: Eicos Sciences, Inc. Not yet recruiting
Conclusions: In our study corn was a common finding in the foot of patients of systemic sclerosis which has not been routinely documented. PMID: 31331136 [PubMed - in process]
Abstract I read with great interest the recent article by Pauling, et al 1, which examined factors influencing Raynaud condition score (RCS) diary outcomes in systemic sclerosis (SSc). Patients with SSc were recruited at sites in both the United Kingdom and the United States and completed the RCS at both baseline and 6 months. PMID: 31308207 [PubMed - as supplied by publisher]
We presented data demonstrating differences in Raynaud symptom reporting using the Raynaud Condition Score (RCS) diary depending on season of enrollment2. PMID: 31308205 [PubMed - as supplied by publisher]
Abstract Systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) and digital ulcers (DU) can impair health-related quality of life (HRQoL). The aim of our study was to estimate HRQoL in SSc patients treated with two different intravenous (IV) iloprost (ILO) regimens and in patients not treated with IV ILO. 96 consecutive SSc patients were enrolled in a pragmatic, prospective and non-randomized study, and divided into 3 groups: not requiring therapy with IV ILO (N=52), IV ILO once monthly (N=24) or IV ILO for 5 consecutive days every 3 months (N=20). Patients were followed up for three months. We assessed HRQoL ...
This report has basically focused on scleroderma renal crisis (SRC), which is the most serious renal manifestation of SSc, characterized by renal failure and sudden onset of hypertension. A 44-year-old man was hospitalized with hypertension, headache, vertigo, nausea, rhinorrhea, reflux, dysphagia, dyspnea (Fc II), visual impairment, mechanical arthralgia, and edema (+3) accompanied by a rare skin lesion. Raynaud's phenomenon was also remarkable in fingers and toes. According to signs and symptoms, SSc diagnosed and the proper treatment was applied. It is of great importance that in the case of malignant hypertension in pa...