Genome-wide RNAi screening identifies RFC4 as a factor that mediates radioresistance in colorectal cancer by facilitating non-homologous end joining repair.

CONCLUSIONS: RFC4 was identified as a radioresistance factor that promotes NHEJ-mediated DNA repair in CRC cells. Additionally, the expression level of RFC4 predicted radiotherapy responsiveness and the outcome of neoadjuvant radiotherapy in LARC patients.
PMID: 30979744 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 11, 2019 Category: Cancer & Oncology Authors: Wang XC, Yue X, Zhang R, Liu TY, Pan Z, Yang MJ, Lu Z, Wang ZY, Peng J, Le LY, Wang G, Peng Q, Meng Y, Huang W, Liu RY Tags: Clin Cancer Res Source Type: research