Individual patient data network meta-analysis using either restricted mean survival time difference or hazard ratios: is there a difference? A case study on locoregionally advanced nasopharyngeal carcinomas

ConclusionThe use of either HR or rmstD impacts the results of NMA. Given the sensitivity of HR to non-proportional hazards, this finding could have implications in terms of meta-analysis methodology.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

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ConclusionIncreased cytotoxicity of NK cells against NPC cells and increased serum levels of biologically active TRAIL in patients treated with IFN β could be a means to eliminate micrometastatic disease and explain the low systemic relapse rate in this patient group.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
This study explored the survival trends and treatment failure patterns of patients with non-metastatic nasopharyngeal carcinoma (NPC) treated with radiotherapy. Furthermore, we evaluated the survival benefit brought by the development of radiotherapy, image technology and chemotherapy based on a large cohort from 1990 to 2012.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
AbstractHead and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and 380,000 deaths worldwide per annum, and account for over 10,000 annual deaths in the United States alone. Improvement in outcomes are needed for patients with recurrent and or metastatic squamous cell carcinoma of the head and neck (HNSCC). In 2016, the US Food and Drug Administration (FDA) granted the first immunotherapeutic approvals – the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab – for the treatment of pa...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Abstract The prevalence of nasopharyngeal carcinoma is characterized by an unbalanced distribution: the disease is particularly prevalent in East and Southeast Asia. In this article, we review the evolution of the International Union Against Cancer/American Joint Committee on Cancer staging system for nasopharyngeal carcinoma. With the increasing using of newer imaging methods, more advanced radiotherapy techniques and systemic chemotherapy, we also discuss newer clinical features that might affect staging. Finally, we propose the future direction of staging and potential prognostic factors that have a major influ...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
To report the outcomes of induction chemotherapy (ICT) followed by chemoradiotherapy (CTRT) for a large cohort of locoregionally advanced nasopharyngeal cancer (LA-NPC) from a non-endemic region.
Source: Clinical Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Our study is the first convincing large ‐scale data to evaluate the characteristics and prognostic value of pre‐retreatment plasma Epstein‐Barr virus (EBV) DNA level for patients diagnosed with Locoregional recurrent nasopharyngeal carcinoma. The pre‐retreatment plasma EBV DNA level could reflect the load of the tumor in patients with locoregional recurrent nasopharyngeal carcinoma, and it was an independent factor for predicting second locoregional recurrence. AbstractPurposeTo define the clinical characteristics and prognostic value of pre ‐retreatment plasma Epstein‐Barr virus (EBV) DNA, we investigated EBV ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
In this study, we investigated structural and functional brain alterations in NPC patients following RT with or without chemotherapy. Fifty-six pre-RT, 37 post-RT and 108 post-CCRT (concomitant chemo-radiotherapy) NPC patients were enrolled in this study. A surface-based local gyrification index (LGI) was obtained from high resolution MRI and was used to evaluate between-group differences in cortical folding. Seed-based functional connectivity (FC) analysis of resting-state fMRI data was also conducted to investigate the functional significance of the cortical folding alterations. Compared with the Pre-RT group, patients i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Nasopharyngeal Carcinoma;   Nasopharyngeal Cancer;   Nasopharynx Cancer Interventions:   Drug: Nab-paclitaxel, Cisplatin and Fluorouracil;   Radiation: concurrent chemoradiotherapy Sponsors:   Guangxi Medical University;   Second affiliated hospital of Guangxi Medical University;   Guilin Medical University, China;   Liuzhou Worker's Hospital;   Wuzhou Red Cross Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractRecent phase 1 –2 trials reported manageable safety profiles and promising antitumor activities of anti-PD-1 drugs (pembrolizumab, nivolumab, camrelizumab and JS001) with/without chemotherapy in recurrent/metastatic nasopharyngeal carcinoma (RM-NPC), however head-to-head comparison among these regimens is lackin g. We aimed to comprehensively compare the efficacy and safety of different anti-PD-1 drugs, standard chemotherapy, and their combination therapy in RM-NPC. Adverse event (AE) and objective response rate (ORR) were assessed. The pooled incidence rates of grade 1–5/3–5 AEs were 74.1%/29.6, ...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
ConclusionPre ‐EBV DNA could be a useful tool to guide individualized treatment for stage II‐III NPC patients. Additional CCT to IMRT improved the survival for patients with high pre‐EBV DNA, while those with low pre‐EBV DNA could not.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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