EV-D68-Associated Acute Respiratory Illness Surveillance EV-D68-Associated Acute Respiratory Illness Surveillance

This report details a preliminary characterization of enterovirus-D68 testing and detection among emergency department and hospitalized patients with acute respiratory illness.Morbidity &Mortality Weekly Report
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

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Conclusions: Viral pathogens were encountered in one-third of hospitalized adult and pediatric Egyptian patients with SARI, while atypical bacteria had a minor role. Highest rates of viral infections were reported for RSV, PIV, and adenovirus. Viral infections had neither negative impacts on clinical features nor outcomes of patients with SARI in our locality. PMID: 30976418 [PubMed]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Multidiscip Respir Med Source Type: research
In this study, human enterovirus C117 (EV-C117) was detected in a 3-month-old boy diagnosed with pneumonia in China. A phylogenetic analysis showed that this strain was genetically closer to the Lithuanian strain than to the USA strain.
Source: Archives of Virology - Category: Virology Source Type: research
AbstractFull-length infectious cDNA clones for recombinant HY12 bovine enteroviruses designated as rHY12-3A-2-HA, rHY12-3A-3-HA, and rHY12-3A-9-HA were constructed by the insertion of an epitope from influenza virus hemagglutinin (HA) at the N-terminus of the HY12-encoded 3A protein at amino acid positions 2, 3, and 9. The recombinant HY12 viruses expressing the HA epitope were rescued and characterized using immunoperoxidase monolayer assay, western blotting, and electron microscopy. The three rescued recombinant marker viruses showed similar characteristics, such as TCID50 titer, plaque size, and growth properties, to th...
Source: Archives of Virology - Category: Virology Source Type: research
In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Tapas Kumar Nayak1†, Prabhudutta Mamidi2, Subhransu Sekhar Sahoo1, P. Sanjai Kumar1, Chandan Mahish1, Sanchari Chatterjee2, Bharat Bhusan Subudhi3, Soma Chattopadhyay2 and Subhasis Chattopadhyay1* 1School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India2Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, India3School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, India Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the maj...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Hand, Foot and Mouth Disease Interventions:   Biological: 36-71 months old children-experimental EV71 vaccine.;   Biological: 36-71 months old children-control EV71 vaccine.;   Biological: 6-35 months old children-experimental EV71 vaccine. Sponsor:   Sinovac Biotech Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, the DHAV-1 CH60 strain may inhibit the expression of IFNα by increasing the SOCS3 protein and SOCS3 can in turn decrease STAT1 and STAT3 mRNA levels, thereby inhibiting the antiviral protein MX1 and ultimately promoting viral proliferation, indirectly assisting in viral adaptation in chicken embryos. Introduction Duck hepatitis A virus type 1 (DHAV-1) is one of the most lethal pathogens for ducks, especially ducklings
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b00115
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
(NEW YORK) — One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping. It was the first sign of an unfolding nightmare. Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe. “It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.” Joey, who survived but still suffers some of the effects, was one of 228...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized illness medical onetime Source Type: news
Conclusions: Continuous surveillance of HFMD etiological agents other than EV-A71 and CV-A16 is necessary. CV-A6 is emerging as the most common pathogen causing HFMD. Closely monitoring the magnitude and trend of CV-A6 epidemic and the trend of pathogenic spectrum changes can provide scientific basis for this disease prevention and control to the department of disease control.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
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