Cognitive Complaints in Memory Clinic and Depressive Patients Cognitive Complaints in Memory Clinic and Depressive Patients

How do cognitive complaints differ among cognitively normal older adults, memory clinic patients, and patients with depression; and which are suggestive of prodromal Alzheimer disease?The Gerontologist
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

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Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractTau oligomers are emerging as a key contributor to the synaptic dysfunction that drives cognitive decline associated with the clinical manifestation and progression of Alzheimer ’s disease (AD). Accordingly, there is ample consensus that interventions that target tau oligomers may slow or halt the progression of AD. With this ultimate goal in mind, in the present study, we investigated tau oligomer accumulation and its synaptic and behavioral consequences after an in vivo treatment with near infrared (NIR) light (600–1000 nm) in two transgenic mouse models, overexpressing human tau either alone (hT...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Subjective cognitive decline (SCD) is characterized by a self-perceived deterioration of cognitive abilities in the absence of objective deficits or depression [1]. Concerns associated with SCD are increasingly acknowledged as risk factor for the development of Alzheimer ’s disease (AD) [1,2] and often affect psychological well-being [3].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
This study identifies the SMN as a cross-network between rLLD- and aMCI-vulnerable networks. The common susceptibility of these diseases to AD is likely due to the breakdown of the cross-network. The results further suggest that interventions targeting the amelioration of sensory-motor deficits in the early course of disease in individuals with AD risk may enhance patient function as AD pathology progresses.
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Publication date: Available online 20 April 2019Source: PhytochemistryAuthor(s): Devashan Naidoo, Martin Pošta, Ayan Roy, Manoj Kulkarni, Johannes Van StadenAbstractSmoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR1 displayed the most encouraging activity returning IC50 values of 13.75 ± 0.001 μM and 0.03 ± 0.02 μM for monoamine oxidase A and B and 0.08 ± 0.006 μM for acetylcholinester...
Source: Phytochemistry - Category: Chemistry Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. A subsample of 271 participants with a diagnosis of probable Alzheimer's disease (AD; N = 50) or mild cognitive impairment (MCI; N = 121) and 100 persons who were not cognitively impaired (NI) were recruited from a large population-based cohort in the island of Crete, Greece (3140 older adults aged>60 years). All participants underwent extensive neuropsychiatric/neuropsychological evaluation and a 3-day 24-hr actigraphy. Objective sleep variables and their association with ne...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Ethicists fear research animals could end up in a 'grey-area - not alive, but not completely dead' Related items fromOnMedica Report helps explain Gulf War illness One in two women and one in three men will develop neurological disease NICE sets care standards for spasticity ‘Suicide tourism’ to Switzerland doubles in four years Head injuries linked to Alzheimer ’s and other disorders
Source: OnMedica Latest News - Category: UK Health Source Type: news
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