Immunosuppressants and Less Steroids in Graves' Orbitopathy Immunosuppressants and Less Steroids in Graves' Orbitopathy
Could combined immunosuppressive therapy help reduce steroid doses in graves'orbitopathy?Clinical Endocrinology
CONCLUSION: A trend toward increasing use of intravitreal anti-VEGF injections for DME treatment was observed in Korea. However, the frequency of dosing and monitoring was lower in clinical practice versus major clinical trials, which may have led to the less-than-favorable improvements in visual outcomes. PMID: 31001935 [PubMed - in process]
CONCLUSION: The addition of AST-120 to conventional treatments may delay the progression of renal dysfunction in diabetic nephropathy. The antioxidant effect of AST-120 might contribute to improvement in renal function. PMID: 31001934 [PubMed - in process]
Publication date: Available online 19 April 2019Source: Chemico-Biological InteractionsAuthor(s): Susmita Barman, Krishnapura SrinivasanAbstractZinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in streptozotocin-induced diabetic rats. Diabetic rats were provided with supplemental zinc for six weeks (5 and 10-times of normal level). Supplemental zinc nurtured ...
Publication date: Available online 19 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Elena V. SuprunAbstractPost-translational modifications (PTMs) occur during or after protein biosynthesis under the action of various specific enzymes or reactive oxygen and nitrogen species. These modifications affect a wide range of protein characteristics such as the size and charge of proteins, their activation state, enzyme activity, cellular localization, interacting partners, and life cycle. Imbalance in protein PTMs can lead to a development of various diseases, among them are cancer and diabetes. It is also genera...
Publication date: May 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 5Author(s):
ConclusionsUnemployment, perception of diabetes’ interference with daily living activities, and social support are significantly correlated with poor glycaemic control. Further studies assessing other important clinical and psychosocial factors that may influence glycaemic control are suggested. A younger age range of participants is recommended for better outcomes and interventional implementation of findings.
Publication date: Available online 19 April 2019Source: Surgery (Oxford)Author(s): Rhys D. Evans, Lisa C. HeatherAbstractMetabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as w...
Conclusions: Recurrent instability was associated with high-energy trauma, time between injury and operation, Mason type III radial head fracture, medial collateral injury, and coronoid nonrepair. Patients with recurrent instability were more likely to require secondary surgery and develop posttraumatic arthritis than those with concentric stability. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
ConclusionsOur findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE and miR-21-3p levels are associated with GDM. Our study for the first time revealed that miR-21-3p, miR-16-5p and miR155-5p are not related to PE-GDM group.
Abstract: Estimates indicate 70% of all individuals with HIV will be age 50 or older by 2030. Chronic conditions, including cardiovascular disease, diabetes mellitus, kidney disease, malignancies, neurocognitive disorders, and osteopenia or osteoporosis, occur more frequently in patients with HIV and have become the leading cause of morbidity in this population. NPs play an integral role in helping this population age healthfully.