Commensal Escherichia coli aggravates acute necrotizing pancreatitis through targeting intestinal epithelial cells.

In conclusion, our study shows that commensal E. coli MG1655 increases TLR4/MyD88/p38 MAPK and ERS signalling-induced intestinal epithelial injury and aggravates ANP in rats. To the best of our knowledge, this is the first study describing the harmful potential of commensal E. coli in ANP.IMPORTANCE To the best of our knowledge, this is the first study describing the harmful potential of commensal E. coli in ANP, which has never been demonstrated by previous studies. Our work provides new insights into the gut bacteria - ANP crosstalk, suggesting that non-pathogenic commensals could also exhibit adverse effects in the context of diseases. PMID: 30979838 [PubMed - as supplied by publisher]
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research