Lung Transplant Outcomes in Pulmonary Fibrosis Patients with Telomere-Related Gene Variants.

CONCLUSION: Rare variants in the telomere-related genes TERT, RTEL1, or PARN are associated with poor post-transplant outcomes among PF lung transplant recipients. Further research is needed to understand the biological mechanisms by which telomere-related variants increase the risk for death and CLAD.
PMID: 30978332 [PubMed - as supplied by publisher]

Source: Chest - April 8, 2019 Category: Respiratory Medicine Authors: Swaminathan AC, Neely ML, Frankel CW, Kelly FL, Petrovski S, Durheim MT, Bush E, Snyder L, Goldstein DB, Todd JL, Palmer SM Tags: Chest Source Type: research