Foregut Function Before and After Lung Transplant

Esophageal dysmotility and gastroesophageal reflux disease (GERD) are common in patients with advanced lung disease, and can potentially affect outcomes of lung transplant (LTx); however, the effects of LTx on foregut function remain unknown. We assessed foregut function before and after bilateral LTx.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research

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Publication date: Available online 22 October 2019Source: Surgery (Oxford)Author(s): Spencer W. BeasleyAbstractOesophageal atresia and tracheo-oesophageal fistula is a congenital structural abnormality that affects 1:4500 live infants. It is due to failure of the primitive foregut tube to separate correctly into oesophagus and trachea. About 50% have associated abnormalities, of which the VACTERL (Vertebral, Anorectal, Cardiac, Tracheo-oEsophageal, Renal and Limb) association is the most common. Prematurity is common and all have some degree of tracheomalacia. Surgery of the common type can be performed through a fourth in...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Authors: Bakhos CT, Petrov RV, Parkman HP, Malik Z, Abbas AE Abstract Gastroesophageal reflux disease (GERD) is quite prevalent worldwide, especially in the western hemisphere. The pathophysiology of GERD is complex, involving an incompetent esophagogastric junction (EGJ) as an anti-reflux barrier, as well as other co-morbid conditions such as gastroparesis, hiatal herniation or hyper acid secretion. Esophageal dysmotility is also frequently encountered in GERD, further contributing to the disease in the form of fragmented peristalsis, ineffective esophageal motility (IEM) or the more severe aperistalsis. The latte...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Gastrointestinal symptoms are common in both inflammatory and non-inflammatory connective tissue disorders and can involve any part of the gastrointestinal tract from the mouth to the anus. Dysphagia, gastrooesophageal reflux, nausea, vomiting, abdominal pain and change in bowel habit are common symptoms and usually arise from gastrointestinal dysmotility and altered visceral sensitivity. In scleroderma, sensorimotor dysfunction is pronounced and can result in complications such as Barrett's oesophagus, gastroparesis, small intestinal bacterial overgrowth, malabsorption and malnutrition, with an associated reduction in survival.
Source: Medicine - Category: Internal Medicine Authors: Tags: New advances Source Type: research
Abstract Eosinophilic esophagitis (EoE) is a multifactorial esophageal inflammation, with a genetic predisposition, which combines a deficient esophageal mucosal barrier, an abnormal immune reaction to environmental allergens mediated by Th2 interleukins, immediate esophageal lesions and dysmotility, with secondary remodeling and fibrosis. Symptoms include reflux, abdominal pain, and food impaction, with a variation according to age. Fibroscopy shows major and minor endoscopic and histologic criteria, with a mucosal count≥15 eosinophils/high power field (Eo/hpf). A new entity has been defined, where gastroesoph...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
Eosinophilic esophagitis (EoE) is a complex allergic disease commonly associated with food-induced symptomatic esophageal dysfunction.1 This includes reflux, dysphagia, and dysmotility.2 Consensus guidelines have provided clinical information to guide EoE evaluation, including the use of proton pump inhibitors (PPIs), to distinguish gastroesophageal reflux disease from EoE, and observations that a unique subset of eosinophilic esophageal infiltration might be largely resolved using a PPI, also termed PPI-REE (PPI-responsive esophageal eosinophilia).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
Abstract BACKGROUND: In adults, distal baseline impedance (BI) is a determinant of esophageal mucosal integrity with values
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0783-2327 Introduction Gastroesophageal reflux disease (GERD) is more frequent in patients with diabetes mellitus (DM).The aim of the present study was to evaluate GER in asymptomatic patients with DM using 24-h pH impedance. Materials and Methods 19 healthy controls and 35 patients with DM without typical GERD symptoms were enrolled in the study. A 24-h pH-impedance study, esophageal manometry and gastroscopy were performed on all patients with DM. In the control group, an impedance study was performed on all subjects, and gastroscopy and esophageal manometry were performed on t...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Background: Gastro-oesophageal reflux disease (GORD) frequently affects bronchiectasis patients and has been associated with increased disease severity and mortality.Methods: We prospectively assessed reflux and microaspiration in sequential, unselected patients with HRCT-confirmed bronchiectasis from 2 centres comparing findings to age, sex, and BMI-matched chronic bronchitis patients and healthy volunteers. Reflux was assessed by questionnaire, high resolution manometry and 24h pH-impedance, and micro-aspiration by measurement of pepsin and bile acids from BAL or sputum. Bronchiectasis severity was assessed by the BSI. Q...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
ConclusionsA tailored partial fundoplication may be effective in symptom relief for non-achalasia patients with esophageal motility disorders and GERD. Significant symptom improvement, low HHR, and PPI use clearly indicate this approach to be effective for this population.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
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