Persistently Elevated Glucagon-Like Peptide 1 Levels Among Critically-Ill Surgical Patients After Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone. Elevated GLP-1 after sepsis is a predictor of death or persistent organ dysfunction. Persistently elevated GLP-1 levels are predictive of death or severe functional disability at 6-months after operation. Persistently elevated GLP-1 levels may be a marker of a non-resolving catabolic state.

Source: Journal of the American College of Surgeons - April 12, 2019 Category: Surgery Authors: Scott C. Brakenridge, Frederick A. Moore, Nicole R. Mercier, Michael Cox, Quron Wu, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron, R Stephen Smith Tags: Western Surgical Association Article Source Type: research