PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors.

CONCLUSIONS: Activation of the PI3K/AKT/mTOR pathway is an oncogenic driver and is associated with xenograft formation in ODs. These findings have implications for therapeutic targeting of PI3K/AKT/mTOR pathway activation in progressive ODs.
PMID: 30975663 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 10, 2019 Category: Cancer & Oncology Authors: Tateishi K, Nakamura T, Juratli TA, Williams EA, Matsushita Y, Miyake S, Nishi M, Miller JJ, Tummala SS, Fink AL, Lelic N, Koerner MVA, Miyake Y, Sasame J, Fujimoto K, Tanaka T, Minamimoto R, Matsunaga S, Mukaihara S, Shuto T, Taguchi H, Udaka N, Murata H Tags: Clin Cancer Res Source Type: research