Effects of different drainage methods on serum bile acid and hepatocyte apoptosis and regeneration after partial hepatectomy in rats with obstructive jaundice.

In conclusion, both internal and external drainage can relieve biliary obstruction. The difference in liver regeneration caused by external drainage and internal drainage may be attributed to the destruction of bile acid enterohepatic circulation, which increases hepatocyte apoptosis and affects liver regeneration. PMID: 30971329 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

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ConclusionIn conclusion, uncovered moving cell SEMS might facilitate bilateral stent deployment using SIS technique.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Asymptomatic abnormal liver function tests (LFTs) are common, affecting 8% of the population. They are mainly caused by alcoholic liver disease and non-alcoholic fatty liver disease, whereas jaundice is most commonly caused by extrahepatic biliary obstruction, followed by alcoholic liver disease and acute liver injury from drugs or viruses. A careful history helps to exclude non-hepatic causes of abnormal LFTs, as well as indicating a potential hepatic cause. Cirrhosis can present with ascites or jaundice, the latter being common in alcoholic liver disease as a result of added injury from alcoholic hepatitis.
Source: Medicine - Category: Internal Medicine Authors: Tags: Assessment of liver disease Source Type: research
Semin Liver Dis DOI: 10.1055/s-0039-1698826Acute kidney injury (AKI) is a dreaded complication in patients with liver disease and jaundice, since it is associated with significant morbidity and mortality. Cholemic nephropathy (CN) is thought to represent a widely underestimated important cause of AKI in advanced liver diseases with jaundice. The umbrella term CN describes impaired renal function along with histomorphological changes consisting of intratubular cast formation and tubular epithelial cell injury directed primarily toward distal nephron segments. In cholestasis, biliary constituents may be excreted via the kidn...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Vascular and Interventional RadiologyAuthor(s): Elisabeth Dhondt, Peter Vanlangenhove, Marc De Man, Lynn Huyck, Luc DefreyneAbstractPurposeTo prove that covered stents are more efficacious than uncovered stents regarding patency, safety, enabling of chemotherapy, and survival in percutaneous palliation of malignant infrahilar biliary obstruction.Materials and MethodsAfter failed endoscopic treatment, 154 patients with obstructive jaundice caused by unresectable infrahilar malignancy were randomly allocated to receive an expanded polytetrafluoroethylene an...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 16 October 2019Source: Journal of EthnopharmacologyAuthor(s): Zhiyong Zhang, Yiru Miao, Min Xu, Wenming Cheng, Chuanyan Yang, Xiangjian She, Qianqian Geng, Qunlin ZhangAbstractEthnopharmacological relevanceTianJiu (TJ) therapy, one type of cold moxibustion, applies to specific acupuncture points with herbal patches of hot nature, providing a constant irritant to the skin until the presence of hyperemia and blistering. Traditional and clinical reports suggest that TJ is an effective therapy for the treatment of jaundice with fresh Ranunculus sceleratus L. (RS), in which protoanemonin is on...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Shubhangi Rathore, Chethan Kumar VK, Sharashchandra RAbstractNeonatal hyperbilirubinemia is the elevation of the bilirubin level in the newborns blood, which results in yellowish staining of the skin and sclera of the newborn eyes by pigment of bile. It is due to the breakdown of RBC's (which release bilirubin into the blood) and the immaturity of newborns liver (which cannot effectively metabolize the bilirubin and prepare it for excretion into the urine). Increased bilirubin production, reduced hepatic clearan...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Acute cholangitis (AC) is characterized by abdominal pain, fever, and jaundice. The majority of the patients respond to medical management with intravenous hydration and antibiotics. Almost 20% to 30% require biliary drainage, and ERCP is the procedure of choice. We conducted a systematic review and meta-analysis to evaluate the impact of emergent biliary drainage on patients ’ outcomes.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Source Type: research
CONCLUSIONS: The serum post-HPE 1-week T-bil level may predict the long-term outcome in BA patients. A post-HPE 1-week T-bil ≤4.85 mg/dL correlated with better native liver survival and jaundice-free native liver survival in BA patients. PMID: 31618755 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
ConclusionBBD could prevent and cure hepatic encephalopathy derived from both chronic and acute liver diseases. Here, we found that except for the direct improvement of blood and brain ammonia level, inflammation is likely an important target of BBD to treat hepatic encephalopathy. The anti-inflammatory role of BBD may lie in its regulation of the TLR4/MyD88/NF-κ B pathways.Graphical abstractBBD can prevent and cure hepatic encephalopathy derived from both chronic and acute liver diseases. BBD can reduce hyperammonemia as well as the systematic and neurological inflammation. Inflammation is likely an important target...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Barcelos STA, Dall'Oglio VM, de Araújo A, Cerski CTS, Álvares-da-Silva MR Abstract Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with n...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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