Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo.

CONCLUSION: Urolithin A protected against ischemic neuronal injury by reinforcing autophagy rather than mitophagy. Autophagy activation by Uro-A attenuated ischemic neuronal death by suppressing ER stress.
PMID: 30972969 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - April 10, 2019 Category: Neuroscience Authors: Ahsan A, Zheng YR, Wu XL, Tang WD, Liu MR, Ma SJ, Jiang L, Hu WW, Zhang XN, Chen Z Tags: CNS Neurosci Ther Source Type: research