Interobserver Agreement for Mismatch Repair Protein Immunohistochemistry in Endometrial and Nonserous, Nonmucinous Ovarian Carcinomas

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is an established test to identify Lynch syndrome (LS) in patients with colorectal cancer and is being increasingly used to identify LS in women with endometrial and/or nonserous ovarian cancer (OC). We assessed interobserver agreement in the interpretation of MMR-IHC on endometrial and ovarian carcinomas. The study consisted of 73 consecutive endometrial cancers (n=48) and nonserous, nonmucinous epithelial OCs (n=25). Six pathologists from 2 cancer centers, one with and the other without, previous experience in interpreting MMR-IHC, evaluated MLH1, MSH2, MSH6, and PMS2 stains. Before the study, an experienced pathologist led a review of 9 teaching cases. A decision tool was developed as a guide in MMR-IHC interpretation. Staining was interpreted as intact, deficient, or equivocal for each protein. Interobserver agreement for the patient MMR status was categorized as “almost perfect” with κ=0.919 (95% CI, 0.863-0.976). All observers were in agreement in 66 (92%) tumors. Four of the less experienced pathologists had at least 1 discrepant interpretation. There were 6 discordant cases: 3 MMR-deficient cases and 2 MMR-intact cases by majority opinion were called equivocal by at least 1 observer, and 1 MMR-deficient case by majority opinion was interpreted as MMR intact by 1 pathologist. Only the latter case (1/73 patients, 1.4%) had an unequivocal disagreement that could affect patient management. Iss...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research

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Publication date: Available online 9 December 2019Source: European UrologyAuthor(s): Christian Radmayr
Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present this case for the uniqueness of the bilateral ovarian pathology as well as to show that robotic-assisted resection of ovarian tumors in certain children is safe and feasible.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
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Source: Cirugia Espanola - Category: Surgery Source Type: research
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Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Cancer Dr. Mallika Marshall Drinking Source Type: news
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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