Liraglutide protects against diabetes mellitus complicated with focal cerebral ischemic injury by activating mitochondrial ATP-sensitive potassium channels

In this study, liraglutide, but not insulin, significantly improved ischemia-induced neurological deficits and decreased infarct volumes following CI in diabetic rats, down-regulated the expression of myeloperoxidase and up-regulated the expression of superoxide dismutase and two subunits of the mitoKATP channel (SUR1 and Kir6.2). However, these effects were weakened by the mitoKATP antagonist 5-hydroxydecanoic acid. Our study demonstrated that the neuroprotective effects of liraglutide on CI injury with diabetes, which occurs by reducing oxidative stress and the inflammatory response, are associated with the activation of the mitoKATP channel.
Source: NeuroReport - Category: Neurology Tags: CLINICAL NEUROSCIENCE Source Type: research