Estimation of thyroid volume from scintigraphy through 2D/3D registration of a statistical shape model.
Estimation of thyroid volume from scintigraphy through 2D/3D registration of a statistical shape model.
Phys Med Biol. 2019 Apr 11;:
Authors: Wang H, Yu D, Tan Z, Hu R, Zhang B, Yu J
Abstract
Accurate measurement of thyroid volume is important for thyroid diseases diagnosis and therapy. In nuclear medicine, the thyroid volume is usually estimated from scintigraphy images using empirical equations. However, due to the missing of volumetric information from the scintigraphy image, the accuracy of equation-based estimation is imperfect. To solve this problem, this paper proposes a method which registers a 3D thyroid statistical shape model (SSM) to a single-view scintigraphy image to achieve more accurate volume estimation. The SSM was constructed based on a training set of segmented 3D CT images, and the thyroid shape variations between the training subjects were modelled using the point distribution model. For thyroid volume estimation, the SSM was projected into the scintigraphy image of the target patient, and then the projected model shape was nonrigidly registered with the patient's scintigraphy image. The resultant 2D deformation filed was back-projected to 3D space to guide the deformation of the 3D SSM. This process was repeated iteratively until convergence, and the volume of the finally deformed SSM was considered as the estimation of the patient's thyroid volume. For validation, this method was evaluated based on a test set ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Wang H, Yu D, Tan Z, Hu R, Zhang B, Yu J Tags: Phys Med Biol Source Type: research
More News: Biology | Nuclear Medicine | Physics | Radioiodine Therapy | Statistics | Thyroid | Training | Universities & Medical Training