Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells

Maintenance of genome integrity is crucial to preserve the function of long-term repopulating hematopoietic stem and progenitor cells (HSPCs) for lifelong blood production. DNA double strand breaks (DSBs) are well-studied cytotoxic DNA alterations that may arise from exposure to cancer therapies, such as ionizing radiation (IR) and chemotherapeutic agents, or from endogenous products of metabolic activities, such as reactive oxygen species (ROS).

Source: Experimental Hematology - April 11, 2019 Category: Hematology Authors: Kacey L. Guenther, Patali S. Cheruku, Ayla Cash, Richard H. Smith, Luigi J. Alvarado, Sandra Burkett, Danielle M. Townsley, Thomas Winkler, Andre Larochelle Tags: Brief Communication Source Type: research