Outcomes of Related and Unrelated Donor Searches Among Patients with Primary Immunodeficiency Diseases Referred for Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with inherited diseases of the immune and hematopoietic system, globally referred to as primary immunodeficiencies (PIDs). Many of the more common and long-recognized PIDs have an autosomal recessive (AR) or X-linked (XL) mode of inheritance, such as Wiskott-Aldrich syndrome, chronic granulomatous disease (CGD), and severe combined immunodeficiency (SCID), wherein patients are typically diagnosed and treated with HCT or gene therapy at a very early age.

Source: Biology of Blood and Marrow Transplantation - April 11, 2019 Category: Hematology Authors: Mary Joseph Acevedo, Jennifer S. Wilder, Sharon Adams, Joie Davis, Corin Kelly, Dianne Hilligoss, Ellen Carroll, Bazetta Blacklock-Schuver, Kristen Cole, Elizabeth M. Kang, Amy P. Hsu, Christopher G. Kanakry, Dimana Dimitrova MD, Jennifer A. Kanakry MD Source Type: research