Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-Dose Toxoplasma gondii Infection

In conclusion, the here provided long-term kinetic survey of immunopathological sequalae in intestinal, extra-intestinal and systemic compartments following peroral low-dose T. gondii infection provides valuable corner stones for a better understanding of the complex interactions within the triangle relationship of (parasitic) pathogens, the host immunity and the commensal gut microbiota during subacute and chronic intestinal inflammation. Furthermore, the low-dose T. gondii infection model may be applied as valuable gut inflammation model in future pre-clinical studies in order to test potential treatment options for intestinal inflammatory conditions in humans (Bereswill et al., 2019). Ethics Statement Following approval by the local authorities for animal experiments (für Gesundheit und Soziales, LaGeSo, Berlin, registration numbers G244/98), mouse experiments were performed in accordance with the European Guidelines for animal welfare (2010/63/EU). Clinical conditions of mice were assessed at least once daily. Author Contributions MH designed and performed experiments, analyzed data, wrote paper. ID critically discussed experimental design and results, co-edited paper. SB provided advice in experimental design, critically discussed results, co-edited paper. Funding This work was supported from the German Federal Ministries of Education and Research (BMBF) in frame of the zoonoses research consortium PAC-Campylobacter to MH and SB (IP7/ 01KI1725D). The funder...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research