Environmental and Clinical Strains of Vibrio cholerae Non-O1, Non-O139 From Germany Possess Similar Virulence Gene Profiles

Conclusion The aim of our study was to determine if STs and virulence gene profiles of clinical and environmental V. cholerae non-O1, non-O139 strains originating from German coastal waters may be correlated and could be usable for a risk assessment of individual strains. The result of this study reveals that – given on the current knowledge about the potential pathogenicity of these strains – no such correlation is found. The MLST shows a high diversity of the bacteria, whereas a basic equipment with virulence genes is very similar between all strains. Due to horizontal gene transfer, in some strains the number of virulence genes is increased compared to other strains. TTSS harboring V. cholerae non-O1, non-O139 strains were discovered in diarrhea causing strains (Dziejman et al., 2005) and recent studies have confirmed the importance of these systems for gastrointestinal infections (Chaand et al., 2015). The clinical strains of our study were mostly isolated from extraintestinal infections (wound infection and otitis) and lacked the genes of the TTSS system with one exception (strain VN-00533). This suggests that other virulence factors play a role in this type of infections. Vibrio cholerae is a species that is a natural inhabitant of aquatic ecosystems. It is likely that most of the factors that contribute to virulence in a human host evolved as a response of these bacteria to challenges in their natural environment (Sakib et al., 2018). Thus, the genetic ma...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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This study used Oswestry Disability Index (ODI)-self-comparison and showed that acupuncture treatments for lumber disc herniation and sciatica demonstrated significant improvement in long term clinical outcomes. A total of 112 lumbar disc herniation and sciatica cases were treated with electric acupuncture for pain relief and function improvement from July 1998 to December 2006.ResultsAll the 112 cases filled out the ODI forms prior to receiving treatment. Among the 112 patients, 23 of them did not finish the 6-week treatments. 89 cases were evaluated with ODI after 6-week acupuncture treatments. Of those 89 cases, 67 case...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
ConclusionsThe therapeutic effect of acupuncture and moxibustion by soothing liver and regulating mind can obviously improve the quality of life of depression elders.
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Publication date: Available online 17 July 2019Source: Global HeartAuthor(s): Jessica Ying-Yi Xie, Matthew R. Solomons, Mahmood Ahmad
Source: Global Heart - Category: Cardiology Source Type: research
ConclusionThis analysis represents the first modern population-based analysis of meningioma incidence and mortality and outcomes of patients with such neoplasms in Germany. Derived from an unselected sample of patients, this study may fill a hitherto existing gap in the literature on meningiomas.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 17 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): John C. Alexander, Biral Patel, Girish P. JoshiAbstractIn the midst of an epidemic of opioid abuse and overdose related morbidity and mortality, the use of opioids remains the most common means of providing analgesia in the perioperative period. In this article, we review the risks and benefits of opioid use in preoperative, intraoperative, and postoperative phases of care. Furthermore, we describe the role that surgeons and anaesthesiologists can play in reducing perioperative opioid use and mitigate their...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Abstract This paper is a commentary on the training of Chinese Primary Health Care Doctors to reduce chronic illness and its burden. First, we will consider the policy position of the Chinese government concerning the development of a competent and enlarged primary physician workforce to deliver the proposed primary health care system reforms. We then turn to a review of the drivers of the high burden of chronic illnesses especially in older people in China. We argue that the curriculum for the training of primary health care medical practitioners should match the demonstrated high prevalence chronic illnesses and...
Source: Australian Family Physician - Category: Primary Care Authors: Tags: Front Public Health Source Type: research
Publication date: October 2019Source: Accident Analysis &Prevention, Volume 131Author(s): Gary A. DavisAbstractAlthough the Highway Safety Manual (HSM) now provides empirical tools for predicting the safety consequences of highway engineering decisions, these tools represent the driver and vehicle conditions prevailing in the United States during the last few decades. As automated vehicles improve in capability and increase in market share these conditions will change, possibly reducing the accuracy of HSM predictions. Assessing the transferability of a crash modification factor to new situations almost certainly requi...
Source: Accident Analysis and Prevention - Category: Accident Prevention Source Type: research
Publication date: 1 November 2019Source: Materials Letters, Volume 254Author(s): Tian Chen, Peifen Wang, Xiao Du, Fengfeng Gao, Xuli Ma, Feifan Liu, Ayman Alameen, Keyong Tang, Xiaogang HaoAbstractA novel hexagonal prism Copper (II) metal organic framework (Cu-BTC) was first synthesized by using a facile unipolar pulse electropolymerization method. It has been found that the morphology of Cu-BTC crystals can be changed from octahedron to hexagonal prism with the increase of pulse cycles. The XRD pattern confirms that the crystal structure of Cu-BTC was slightly affected by the change of the crystal morphology. Furthermore,...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: 1 November 2019Source: Materials Letters, Volume 254Author(s): Jiesong Zhang, Zhihang Liu, Daoping Cai, Hongbing ZhanAbstractDeveloping facile strategies to synthesize transition metal oxides and nitrogen-doped carbon (NC) hybrid materials is important for lithium-ion batteries (LIBs) but also challenging. Herein, unique one-dimensional multicomponent MoO2@CoO-CoMoO4-NC hybrid nanorods have been successfully synthesized. Benefiting from the unique morphology, structure and components, the MoO2@CoO-CoMoO4-NC hybrid nanorods exhibit a high reversible discharge capacity of 1164.0 mA h g−1 at 200...
Source: Materials Letters - Category: Materials Science Source Type: research
ConclusionsBased on the population data and our case series, COQ4-related mitochondriopathy is likely an underrecognized condition. We recommend including the COQ4 c.370G > A variant as a part of the screening process for mitochondriopathy in Chinese populations.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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