Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis

We report that depletion of WHS-associated genes is a potent effector of neural crest-derived tissues, and suggest that this explains why WHS clinical presentation shares so many characteristics with classic neurochristopathies. Ethics Statement All experiments were approved by the Boston College Institutional Animal Care and Use Committee and were performed according to national regulatory standards. Author Contributions LL, AM, and EB contributed conception and design of the study. EB, AM, RC, SK, MS, and SL performed the experiments and analyzed the data. EB wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version. Funding This work was supported by the NIH National Institute of Dental and Craniofacial Research (R03 DE025824), the NIH National Institute of Mental Health (MH109651), the March of Dimes (1-FY16-220), and the American Cancer Society (RSG-16–144-01-CSM). EB was funded by a National Science Foundation Graduate Research Fellowship. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank members of the LL Lab for helpful discussions, suggestions, and editing. We also thank Eric Snow, Mitchell Lavoie, Katya Van Anderlecht, Katherine Montas, Lucas Ashley, and Molly Connors for technical assistance. We thank N...
Source: Frontiers in Physiology - Category: Physiology Source Type: research