Effect of Cervus and Cucumis Polypeptide Combined with Zoledronic Acid on Bone Metabolic Biochemical Markers in Glucocorticoids - Induced Osteoporosis Patients

Publication date: Available online 11 April 2019Source: Saudi Journal of Biological SciencesAuthor(s): Dacheng Han, Anhua Long, Jialong Wang, Xuefei Wang, Yakui ZhangAbstractObjectiveTo investigate the effect of cervus and cucumis polypeptide combined with zoledronic acid on bone metabolic biochemical markers in glucocorticoids - induced osteoporosis patients.MethodsA total of 100 patients with glucocorticoids - induced osteoporosis admitted to our hospital from January 2015 to June 2017 were enrolled in this study. Patients were divided into observation group and control group by random number table method, 50 cases in each group. Patients in the observation group were treated with deer melon polypeptide in combination with zoledronic acid, and patients in the control group were treated with zoledronic acid alone. The patients in both groups were treated for 2 months. The changes of bone mineral density (BMD) and biochemical markers of bone metabolism in lumbar vertebrae L1-4, left femoral neck and large trochanter were analyzed before and after treatment.ResultsThe pre- BMD at lumbar spine L1-4, left femoral neck and great trochanter had no statistic difference (P>0.05), the BMD at each sites improved after treatment, and the difference were statistical before and after treatment (P
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research

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