XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia.

CONCLUSION: A positive feedback bistable ERN2-XBP1S pathway regulates MUC5B-dominated mucus obstruction in IPF, providing a UPR-dependent mechanism linking the MUC5B promoter rs35705950 polymorphism with IPF pathogenesis. Inhibiting ERN2-dependent pathways/elements may provide a therapeutic option for IPF. PMID: 30973754 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30973754?dopt=Abstract

Source: American Journal of Respiratory and Critical Care Medicine - April 10, 2019 Category: Respiratory Medicine Authors: Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC Tags: Am J Respir Crit Care Med Source Type: research

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