Aberrant methylation status of SPG20 promoter in Hepatocellular Carcinoma: a potential tumor metastasis biomarker

Hepatocellular carcinoma (HCC) is the sixth highest malignant tumor in the world. Because of its complicated pathogenesis, high recurrence, metastasis rate and tumor heterogeneity, HCC has become the third most frequent cause of cancer-related death (1). However, the 5-year survival of HCC patients can achieve higher than 50% when diagnosis at early stages (2).Therefore, a better understand of the pathogenesis for HCC is critical to improve the prognosis of patients with HCC through early diagnosis and treatment.

Source: Cancer Genetics and Cytogenetics - April 11, 2019 Category: Genetics & Stem Cells Authors: Lifeng He, Xiaoxiao Fan, Yirun Li, Bin Cui, Zhaoqi Shi, Daizhan Zhou, Hui Lin Source Type: research