Second reported case of pediatric bladder alveolar soft part sarcoma as secondary malignancy after prior cytotoxic chemotherapy

Alveolar soft part sarcoma (ASPS) is a rare malignancy with high rates of metastasis at presentation, defined by an unclear cellular origin and a unique unbalanced ASPSCR1-TFE3 translocation (der(17)t(X:17)(p11:q25))1. ASPS is insensitive to chemotherapy and has been reported to involve the bladder only twice in the pediatric literature; once as a primary malignancy2, and once as a secondary malignancy after cytotoxic chemotherapy3. Herein, we report the third case of pediatric bladder ASPS in a female patient who received cytotoxic chemotherapy for low-risk neuroblastoma.

Source: Urology - April 11, 2019 Category: Urology & Nephrology Authors: Justin Penticuff, Sarah McDermott, Alonso Carrasco, Paul Bowlin, Karen Lewing, Joel F Koenig Source Type: research