Scientist finds skin deep is very deep

Valentina Greco has made singular contributions to knowledge about the function of skin cells, some of which may limit cancer and aid stem cell regeneration.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Today's open access paper is a companion piece to a recent discussion of repetitive element activity as a potential biomarker of biological aging. In today's paper, the authors note that a number of interventions that modestly slow aging in mice also reduce the activity of repetitive elements in the genome. Many forms of repetitive element are the remnants of ancient viruses, sequences that are capable of copying themselves into new locations in the genome, but are normally suppressed. A fair amount of attention has been given to retrotransposons, one category of repetitive elements, in the context of aging in recent years...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
CONCLUSIONS: The frequency of HRCs with HDSG in both bone marrow and spleen was increased 1 week after X-irradiation. Then, the frequency of HRCs with HDSG in bone marrow showed a gradual decrease from 4 to 26 weeks, whereas HRCs with HDSG in spleen remained high, even at 26 weeks after X-irradiation. The different responses may reflect differences in hematopoietic cell dynamics in bone marrow and spleen. HDSG is less likely to be eliminated, particularly in the spleen, after X-irradiation. The spleen as well as bone marrow of the femur may be major sites of rAML development. PMID: 32658559 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) has become a standard part of therapy for a variety of malignant and non-malignant disorders. With improved outcomes after HSCT, increasing attention has been drawn to late complications in long-term survivors. The development of secondary malignancies is recognized as one of the most serious complications. We have evaluated data in 426 patients (272 males, 154 females) who underwent allogeneic transplantation at median age of 7.9 years from 1989 till 2017 and were alive more than one year after transplantation for the occurrence of secondary solid...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
Garg Khattar Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells, eventually resulting in replicative senescence once telomere length becomes critically short. Telomere shortening can be overcome by telomerase enzyme activity that is undetectable in somatic cells, while being active in germline cells, stem cells, and immune cells. Telomeres are bound by a shelterin complex that regulates telomere lengthening as well as protects them from ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Haplo-identical transplant activity has significantly increased recently, with highest increase seen in South East Asia/West Pacific region (48.6%), followed by Europe (29.9%) and the Americas (19.8%)1 . The most common platforms to overcome HLA-mismatching are: 1) Anti-thymocytic globulin (ATG)-based and 2) Post-transplant cyclophosphamide-based (PTCy). The ATG-based platform is used extensively in China and involves use of G-CSF mobilised peripheral stem cells as well as G-CSF primed bone marrow.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Hot Topic Source Type: research
Better understanding the CD8+ T cells already present in tumors could be key to making immunotherapies work for more patients.
Source: The Scientist - Category: Science Tags: Features Magazine Issue Source Type: news
(Technical University of Munich (TUM)) An adenovirus infection can be potentially life-threatening, especially for children after a stem cell transplant. Virologists at the Technical University of Munich (TUM) and the German Research Center for Environmental Health Helmholtz Zentrum M ü nchen have successfully shown that a previously approved medication used in cancer treatment could help inhibit this virus infection. Due to the special mechanism of action, the virus cannot develop defence strategies.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 12 July 2020Source: Pathology - Research and PracticeAuthor(s): Eric Gyan, Linda Ahenkorah Fondjo, William Owiredu, Andrew Jackson, Andrew Green
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) g...
Source: BMC Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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