An Herbal Drug Called Kratom Has Been Linked to Almost 100 Overdose Deaths, the CDC Reports

Kratom, an over-the-counter substance often marketed as a health supplement for pain relief, was found to be a cause of at least 91 overdose deaths in the U.S. between 2016 and 2017, according to a Center for Disease Control and Prevention (CDC) report published Friday. The figure is more than double a Food and Drug Administration (FDA) estimate of 44 known deaths associated with kratom since 2011. The CDC’s study examined more than 27,000 overdoses in 27 states from July 2016 and December 2017. In seven of the 91 cases in which kratom was determined to be a cause of death, the drug was the only substance to test positive in a toxicology report, though additional substances could not be ruled out. Kratom use has increased in recent years, according to the CDC. The kratom plant is grown in Southeast Asia, where it is considered a natural health treatment for common maladies like fevers and coughs. When consumed, kratom acts as a stimulant and produces opioid-like effects. In the U.S., it’s been touted as an alternative to opioid painkillers and even an effective way to help people overcome opioid addiction. Last year, however, the FDA said kratom contains the same addictive, potentially dangerous chemicals found in opioids. While kratom is not a scheduled controlled substance, the FDA issued a warning in November 2017 advising consumers not to use the drug due to fears that it could expose users to risks of addiction, abuse and dependence. The Drug Enforcement Adm...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime overnight Research Source Type: news

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Authors: Ross B, Ross SB Abstract Gingival recession is a component of periodontal disease that leads to exposure of the root surface, root hypersensitivity, and esthetic concerns. Treatment of these cases is typically performed with autologous grafts harvested from the palate. However, this is associated with a second surgical site that increases surgical time and patient morbidity. A potential alternative is the use of cryopreserved umbilical-cord allografts, which are known to contain anti-inflammatory properties and have been used clinically by numerous medical specialties. In this observational series, three p...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
Authors: Lai HC, Lin YW, Hsieh CL Abstract Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition a...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Corrigendum to "Old and New NICE Guidelines for the Evaluation of New Onset Stable Chest Pain: A Real World Perspective". Biomed Res Int. 2019;2019:9637490 Authors: Carrabba N, Migliorini A, Pradella S, Acquafresca M, Guglielmo M, Baggiano A, Muscogiuri G, Valenti R Abstract [This corrects the article DOI: 10.1155/2018/3762305.]. PMID: 30984787 [PubMed]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
(Elsevier) To improve the treatment of children with irritable bowel syndrome (IBS), investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut. A report in The Journal of Molecular Diagnostics, published by Elsevier, describes how a new battery of tests enables researchers to distinguish patients with IBS from healthy children and identifies correlations between certain microbes and metabolites with abdominal pain. With this information, doctors envision tailoring nutritional and targeted therapies that address a child's specific gastrointestinal problems.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Abstract Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Rats in the colitis g...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Authors: Kim MG, Ahn YS Abstract The aims of this study were to (1) compare the prevalence of LBP in firefighters according to job type and (2) identify the risk factors of LBP. A random sample of 277 male firefighters and 72 hospital office workers completed questionnaires and underwent lumbar spine MRI. The prevalence of LBP in firefighters (85.1%) was higher than in controls (54.5%). The odds ratio (OR) of LBP and severe insomnia (3.84, 95% CI [1.17, 12.06]) was statistically higher than LBP without insomnia. The OR of LBP and herniated lumbar disc 4-5 (1.86, 95% CI [1.03, 3.35]) was statistically higher than th...
Source: International Journal of Occupational Safety and Ergonomics - Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research
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Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Trends and Innovations Source Type: news
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Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Best of the Rest Source Type: news
Rockland County health officials order new restrictions and requirements to stem the ongoing and worsening measles outbreak in the New York City suburb.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
We report the case of a patient with a lengthy psychiatric history who presented with lower extremity pain and weakness. Cervical, thoracic, and lumbar MRI scans with and without gadolinium contrast revealed no significant stenosis, neural compression, or other abnormal findings, and the brain MRI with and without gadolinium contrast was normal. The initia l diagnosis was conversion disorder due to myriad psychological stressors. Polymerase chain reaction (PCR) of CSF detected HSV-2 and a lymphocytic pleocytosis, and the diagnosis of radiculomyelitis was confirmed. She was treated with i.v. acyclovir for 3 weeks followed b...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
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