The Week That Wasn't: Snail Glue Sutures, Helpful Jet Lag, Viral Cancer Cure The Week That Wasn't: Snail Glue Sutures, Helpful Jet Lag, Viral Cancer Cure

This week's stories include surgical sutures made of snail glue, jet lagged fruit flies, and a potential viral cure for a pediatric cancer.Medscape
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Medscape Today Article Source Type: news

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ConclusionUsing structured data, we accurately classified patients’ cancer risk group, identified bone scan documentation with two NLP methods, and evaluated guideline adherence. Our pipeline can be used to provide concrete feedback to clinicians and guide treatment decisions.Graphical abstract
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Publication date: Available online 20 April 2019Source: Saudi Pharmaceutical JournalAuthor(s): Omar M. Noman, Ramzi A. Mothana, Adnan J. Al-Rehaily, Ali S. Al qahtani, Fahd A. Nasr, Jamal M. Khaled, Mohamed F. Alajmi, Mansour S. Al-SaidAbstractThe Loranthus genus has been demonstrated to be used in the treatment of wide range of diseases e.g. diabetes, inflammations and cancers. Many species of Loranthus represent a major source of biologically active constituents. Therefore, our study was carried out to investigate the anti-diabetic, anti-inflammatory and antioxidant effects of Loranthus acaciae Zucc. (Loranthaceae) grown...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
In this study, we devised a simple industrial method to manufacture lipoplex, which includes short hairpin RNA against the expression of thymidylate synthase (TS shRNA) — a key molecule for DNA biosynthesis. An aqueous solution of TS shRNA was gently mixed with either a precursor of cationic liposome (Presome DF-1) or a cationic lipid mixture in an o/w emulsion. This solution was subsequently lyophilized under optimal conditions to obtain either FD-lipoplex-1 or FD-lipoplex-2, respectively. With this method, a lipoplex in activated form was obtained via a simple “one-step” hydration with saline. Both form...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: June 2019Source: Cancer Epidemiology, Volume 60Author(s): Marie Poiseuil, Gaëlle Coureau, Catherine Payet, Marianne Savès, Marc Debled, Simone Mathoulin-Pelissier, Brice AmadeoAbstractBackgroundSome studies have investigated the role of socio-demographic inequalities in the association between screening and survival. However, in France, no study has been conducted to describe the socio-demographic characteristics and survival of women with breast cancer based on their participation to mass screening. The aim of this study was to assess the impact of socio-demographic inequalities on the associ...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionThe consistent association with educational attainment suggests low health literacy may play a role in CUP diagnosis. These findings highlight the need to develop strategies to achieve earlier identification of diagnostically challenging malignancies in people with low health literacy.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionPrevalence of H. pylori infection in LAC is high for all age groups. These data reinforce the necessity of actions towards the prevention and treatment of H. pylori infection for all age groups. Treating H pylori infection in young ages probably will reduce gastric cancer incidence in the future.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
This study evaluates NLR in a large cohort of HCC patients. Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. NLR was stratified into NLR ≥1.5 and NLR ≥3 and analyzed for correlation with American Joint Committee on Cancer (AJCC) and Barcelona Clinic Liver Cancer (BCLC) stages. In 235 patients who underwent liver resection, survival and recurrence were evaluated by NLR. Results: In 789 HCC cases, mean NLR was increased with advanced AJCC and BCLC stages. Hepatitis C patients were less likely to have NLR ≥1.5 and ≥3. Non-alcoh...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
CONCLUSIONS: HOXD-AS1 may be a prognostic biomarker and potential therapeutic target for various tumor diagnosis and treatment. PMID: 31002165 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: The above studies demonstrated that microRNA-129-5p was strikingly correlated with LCa lymph node or distant metastasis and poor prognosis, and it can inhibit the malignant progression of this cancer. The investigation also demonstrated that microRNA-129-5p may inhibit proliferation capacity and invasiveness of LCa cells and tumor angiogenesis via regulating VEGF. PMID: 31002164 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study aimed to investigate the effects of Cur on proliferation and apoptosis of colorectal cancer cells. MATERIALS AND METHODS: Human normal colorectal epithelial cell line (NCM460) and colorectal cancer cell line (SW480 and SW620) were cultured in vitro. Real-time quantitative PCR (RT-PCR) and western blot were used to detect DJ-1 and PTEN mRNA and protein, respectively. Cell apoptosis was determined with flow cytometry. SW480 cells were divided into control, 20 μM Cur treatment group, Cur+pcDNA3.1-Blank group and Cur+pcDNA3.1-DJ-1 group. Cell proliferation activity was evaluated with EdU staining. RESULTS...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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