Medical News Today: A special 'stained glass' can help kill hospital 'superbugs'

Researchers have developed a new type of bioactive glass, stained with cobalt, which allows it to kill many dangerous strands of bacteria and fungi.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

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by Marko J ärvenpää, Mohamad R. Abdul Sater, Georgia K. Lagoudas, Paul C. Blainey, Loren G. Miller, James A. McKinnell, Susan S. Huang, Yonatan H. Grad, Pekka Marttinen Bacterial populations that colonize a host can play important roles in host health, including serving as a reservoir that transmits to other hosts and from which invasive strains emerge, thus emphasizing the importance of understanding rates of acquisition and clearance of colonizing populations. Studies of colonization dynamics have been based on assessment of whether serial samples represent a single population or distinct colonization eve...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Publication date: Available online 20 April 2019Source: Microbial PathogenesisAuthor(s): B.F. Rossi, E.C.R. Bonsaglia, I.G. Castilho, S.T.A. Dantas, A. Salina, H. Langoni, J.C.F. Pantoja, P.E. Budri, D. Fitzgerald-Hughes, A. Fernandes Júnior, V.L.M. RallAbstractBovine mastitis affects dairy cattle worldwide and Staphylococcus aureus is one of the most common microorganisms involved in subclinical and chronic disease. Superantigens, such as enterotoxins contribute to S. aureus persistence and pathogenicity in this disease. Subclinical and chronic mastitis cases were diagnosed and S. aureus isolates from sub-clinical ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 20 April 2019Source: Food ControlAuthor(s): Ahmed Abdel-Hameid Ahmed, Nagah Mohammed Saad Maharik, Antonio Valero, Sahar Mahmoud KamalAbstractStaphylococcus aureus (S. aureus) is one of the most concerning foodborne pathogens due to its ability to produce wide varieties of heat-stable enterotoxins. Hence, this study was designed to investigate the prevalence of the enterotoxigenic S. aureus strains and their enterotoxins in milk and in some representative artisanal Egyptian dairy products. Additionally, the prevalence of Methicillin-Resistant S. aureus (MRSA; antibiotic resistant strain) ...
Source: Food Control - Category: Food Science Source Type: research
Conclusion: It is important to know about the prevalence of resistance and rising MIC values of commonly used antibiotics regarding Streptococcus pyogenes to avoid therapeutic failures. PMID: 30996826 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
The human skin is colonized by a diverse array of bacteria, archaea, fungi, and viruses. Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) as well as the relative absence of methicillin resistant Staphylococcus aureus (MRSA) on healthy skin. A widely recognized mechanism of bacterial competition is the quorum sensing Accessory Gene Regulator (agr) system, ubiquitous among staphylococci. We hypothesize that agr signaling facilitates interspecies cross-talk between CoNS and MRSA, resulting in a colonization advantage for CoNS and protecting the host from MRSA colonization or infection.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
IL-1 β/IL-1R/MyD88-signaling is critical in mediating neutrophil recruitment and host defense against S. aureus skin infections but the cells that respond to IL-1β to trigger the protective IL-1R-dependent immune response are unclear. To evaluate the relative contribution of different IL-1R-expressing cell types against a community-acquired methicillin-resistant S. aureus (CA-MRSA) skin infection, a CA-MRSA strain (USA300 LAC::lux; 3x107 CFU) was inoculated intradermally into cre/lox mice with specific deletion of IL-1R in which IL-1R-floxed mice (IL-1Rfl/fl) were bred to mice with cre-specific e xpression in ker...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
Resistant Propionibacterium acne strains can limit the efficacy of currently-used antibiotics and is emerging as a clinical challenge. There is an urgent need for new drugs that are effective against these resistant strains to treat moderate to severe inflammatory acne. Here we tested the safety, tolerability, and efficacy of VB1953, a topical 2% gel, applied b.i.d. over 12 weeks in an open label, single arm study in patients with clindamycin non-respondent/resistant acne vulgaris. Inclusion criteria were (i) moderate to severe (IGA grade 3 or 4) acne, (ii) at least 20 inflammatory and at least 20 non-inflammatory lesions;...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Interventional Studies, Clinical and Patient Outcomes Research Source Type: research
Ross Hill Bacteriophages (phages) or bacterial viruses have been proposed as natural antimicrobial agents to fight against antibiotic-resistant bacteria associated with human infections. Enterococcus faecalis is a gut commensal, which is occasionally found in the mouth and vaginal tract, and does not usually cause clinical problems. However, it can spread to other areas of the body and cause life-threatening infections, such as septicemia, endocarditis, or meningitis, in immunocompromised hosts. Although E. faecalis phage cocktails are not commercially available within the EU or USA, there is an accumulated eviden...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
In the study, researchers tested 399 hospital patients and found that 14% had superbugs on their hands or nostrils right after admission. Superbugs were also found on items commonly touched by patients, such as the nurse call button, in nearly one-third of tests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusion: spa typing can be performed to screen for transmission of S. aureus. t786, ST88, and SCCmec IVa MRSA strains were identified for the first time in Turkey. PMID: 30997982 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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