Medical scopes still causing superbug infections and deaths, FDA says

Three people died and 45 people developed infections from contaminated endoscopes, the US Food and Drug Administration said Friday.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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In this study, we firstly tested the effects of QJSB on leucopenia using mice induced by cyclophosphamide. Our results suggested that QJSB significantly raised the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Additionally, it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. Furthermore, it reversed the serum cytokines IL-6 and G-CSF disorders. Then, using transcriptomics datasets and metabonomic datasets, we integrated transcriptomics-based network pharmacology and metabolomics technologies to investigate the mechanism of action o...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions In conclusion, this investigation indicated that citral attenuated multiple virulence factors of V. parahaemolyticus, including QS, motility, biofilm formation, the adhesion to Caco-2 cells, and repressed the expression of genes related to flagella (polar and lateral), biofilm and T3SS1 effectors, virulence regulators (luxS, aphA and toxR), and AMP resistance. The results obtained in this work demonstrate the inhibitory effect of citral on virulence factors of V. parahaemolyticus. However, the data reported in this study only demonstrate the anti-virulence effect of citral in vitro. Further research is needed ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion The results of our study demonstrate that robenidine is not suitable as a sole antimicrobial agent for the treatment of Gram-negative pathogen infections due to the lack of activity against the majority of Gram-negative isolates except for A. baumannii and A. calcoaceticus. However, we demonstrated in vitro efficacy against all selected Gram-negative organisms when robenidine was tested in combination with EDTA or PMBN, including against multidrug-resistant strains. Therefore, robenidine may be an appropriate candidate as a component of a combination preparation for the treatment of otitis externa in dogs. This...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Charmaine N. Nganje, PREP scholar at Tufts University in Boston. Credit: Katherine Suarez. Charmaine N. Nganje Hometown: Montgomery Village, Maryland Influential book : The Harry Potter series (not exactly influential, but they’re my favorite) Favorite movie/TV show: The Pursuit of Happyness/The Flash Languages: English (and a bit of Patois) Unusual fact: I’m the biggest Philadelphia Eagles fan from Maryland that you’ll ever meet Hobbies: Off-peak traveling Q. Which NIGMS program are you involved with? A. The Postbaccalaureate Research Education Program (PREP)  at the Sac...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Being a Scientist Bacteria Diseases Infection Infectious Disease Infectious Diseases Training Source Type: blogs
Authors: Khien VV, Thang DM, Hai TM, Duat NQ, Khanh PH, Ha DT, Binh TT, Dung HDQ, Trang TTH, Yamaoka Y Abstract Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, anti...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
ConclusionThese results are suggestive that the R-plasmids could possess substrate for capsaicinoids-like compounds and for their ability to inhibit the plasmid conjugation processes. Plant natural products possess the potential value of antibacterial and mechanistic antiplasmid activity as demonstrated by the compounds and should be evaluated in developing antimicrobial leads to novel mechanism against multidrug resistant bacteria.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b02643
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
In this study we examined the influence of ultra-small gold and magnetite‑gold nanoparticles (NPs) stabilized with d,l-methionine, Fe3O4@Au@Met, on their antibacterial efficacy against three of twelve the worst bacterial family members included in the World Health Organization (WHO) list. In particular, gram-negative Acinetobacter baumannii, Salmonella enterica and gram-positive methicillin-resistant Staphylococcus aureus and Micrococcus luteus were tested. Apart from the synthesis, gold species reduction and NP stabilization, an excess of methionine has been used herein to detach ultra-small gold NPs from the Fe3O4@Au@M...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
This study identified prophages as mediators of bacterial virulence in a model of infectious endocarditis, probably through promotion of interaction with extracellular matrix components. Further studies are needed to identify mechanisms leading to promotion of intrinsic virulence. Introduction Challenges related to Staphylococcus aureus infections in the human and veterinary clinics mobilized important human and technical resources. S. aureus can colonize 20–30% of the general population asymptomatically but is also capable of causing a wide spectrum of diseases ranging from benign infections, to particularly...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: To the best of our knowledge, this study provides the first evidence for polymorphisms of the class 1 integron variable promoter in clinical Proteus isolates, which generally contain relatively strong promoters. Resistance genotypes showed a higher coincidence rate with the drug-resistant phenotype in strong-promoter-containing strains, resulting in an ability to confer strong resistance to antibiotics among host bacteria and a relatively limited ability to capture gene cassettes. Moreover, strains with relatively weak integron promoters can “afford” a heavier “extra-integron antibiotic resist...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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