What ultimately changed the mind of a mother who refused to vaccinate her kids

Kristen O'Meara chose not to vaccinate her children, despite longstanding scientific evidence that show that vaccines are proven to be safe, and there is no link between receiving vaccines and developing serious or chronic illnesses. But after her family fell ill, she began to change her tune on vaccines.
Source: CBC | Health - Category: Consumer Health News Tags: Radio/Out in the Open Source Type: news

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Publication date: Available online 20 April 2019Source: BiologicalsAuthor(s): Mozhdeh Namvarpour, Majid Tebianian, Reza Mansouri, Seyyed Mahmoud Ebrahimi, Shiva KashkooliAbstractAccording to some difficulties against tuberculosis (TB) vaccination, development of new TB vaccines has been noted in recent years. Selection of proper route for vaccination is one of the most important factors for induction of good immune responses. Hence, in this study, the effects of different administration routes, including intranasal (I.N), subcutaneous (S.C) and intramuscular (I.M) on immune responses against Mycobacterium tuberculosis ESAT...
Source: Biologicals - Category: Biology Source Type: research
Authors: Kashikar SV, Lakhkar B, Pandey A, Gupta A Abstract An adolescent presented with headache and projectile vomiting and showed ataxia, dysarthia and nystagmus with normal cognition. A diagnosis of acute cerebellitis was made on the basis of computed tomography and magnetic resonance imaging findings. He developed seizures and had a rapid downhill course with death at 48 hours after admission. Clinically, patients of acute cerebellitis present with fever, nausea, headache and altered sensorium with cerebellar symptoms. Inflammation of the cerebellum compresses the brain stem and induces mental alterations. It ...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Publication date: Available online 19 April 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): S. Cecchini, D. Rufrano, A.R. CaputoAbstractNatural antibodies (NAb) are antibodies that can bind to a particular antigen without any apparent antigenic stimulation. In this paper, a careful analysis has been carried out on NAb levels in goat kid serum; possible correlations with the total immunoglobulin (tot-Ig) levels and specific antibody (SpAb) response were considered. Twenty randomly chosen kids were submitted to a first blood sampling (day 0). After 60 and 100 days, new blood samplings were carried out in the ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Publication date: Available online 19 April 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): S. Jimbo, P.J. Griebel, K. Lai, L.A. Babiuk, G. MutwiriAbstractRegulatory B cells that produce IL-10 are now recognized as an important component of the immune system. We previously confirmed that IL-10 secreting CD21+ regulatory B cells (Breg cells) were present in ovine jejunal Peyer’s patches (JPP) and this IL-10 production suppressed IL-12 and IFN-γ secretion. It is not known, however, whether ovine Breg cells are restricted to JPP or are present in other lymphoid tissues. Therefore, CD21+ B cells wer...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Publication date: Available online 20 April 2019Source: Carbohydrate PolymersAuthor(s): Wei Zou, Jianjun Li, Evguenii Vinogradov, Andrew CoxAbstractPneumococcal cell wall polysaccharide (C-PS), a contaminant in pneumococcal capsular polysaccharide (Pn-PS) vaccines is degraded by mild deamination of the 4-amino-2-acetamido-2,4,6-tri-deoxy-galactose (AAT) in C-PS, which was carried out by addition of 5% aqueous sodium nitrite to a solution of polysaccharide in 5% aqueous acetic acid. Glycosidic linkage and functional groups such as O-acetates, phosphodiesters, and pyruvates were preserved under the conditions. The small frag...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 April 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): C. Benedetto, A. Carosso, M. Corezzi, C.M. Zotti, on behalf of EBCOGAbstractMaternal immunization has the potential to reduce morbidity and mortality from infectious diseases worldwide. EBCOG promotes this public health intervention supporting international recommendations about the use of vaccines during pregnancy.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Authors: Yamaoka K Abstract INTRODUCTION: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Expert commentary: The efficacy of tofacitinib monotherapy has garnered much attention and has been initiated in a fairly larg...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Contributors : Min Zhang ; Jason Westin ; Zhiqiang Wang ; Larry W Kwak ; Sattva S Neelapu ; Wencai Ma ; R E DavisSeries Type : Expression profiling by arrayOrganism : Homo sapiensExcisional biopsies of lymph nodes involved by follicular lymphoma (FL) were obtained from previously-untreated, advanced-stage patients to generate heterohybridomas and idiotype vaccine for a clinical trial (PMID: 21632504). Residual, viably-cryopreserved suspensions of disaggregated cells were magnetically sorted by negative selection into nominal B (CD3-depleted) and non-B (NB; CD19- and CD20-depleted) fractions. Total RNA was extracted from ea...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conclusion: In explanation, lack of efficient disease control measures, has possibly contributed in evolution of a clone or a few clones that gradually overwhelmed the population over the time. Besides, the similarity between the Iranian and the PG2 strains, might be due to homoplasy or farming exercises such as animal importation. Inclusion of further local isolates in next studies will help to assess these assumptions. PMID: 30996831 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
This study aimed to investigate the immunogenicity of LcpA (rLcpA) and LenA (rLenA) recombinant proteins in combination with LTB (rLTB) recombinant protein as an adjuvant against leptospiral infection in hamsters. Materials and Methods: The genes encoding these proteins were cloned into pGH cloning vector and then lenA, lcpA and ltb genes subcloned into pET-15b and pET-28a expression vectors, respectively. The hamsters were immunized with the purified recombinant proteins and challenged with Leptospira interrogans for evaluation of their survival. The antibody responses to the recombinant proteins were determined by EL...
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
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