Novo Nordisk and Gilead team up to test fatty liver disease treatment

Novo Nordisk and Gilead Sciences will join forces on a clinical trial combining drugs from the two pharmaceutical firms to treat a progressive fatty liver disease known as NASH.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the pathogenesis of fatty liver diseases. Necroptosis is regulated by three key proteins: receptor-interacting serine/threonine kinase 1 (RIP1; official name RIPK1), RIP3, and mixed lineage kinase like protein (MLKL). Here, we found that western diet (WD) induced marked steatosis in mouse livers, which was associated with the inhibition of hepatic proteasome activities and increased levels of key necroptosis proteins.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study. Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday. After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Disease Source Type: news
ConclusionOnly a small number of ALT tests performed during MTX therapy in RA capture an elevation. A pre ‐treatment elevation of ALT was the strongest predictor for early and recurrent ALT elevations during therapy. This study supports a more individualized approach to monitoring and handling of ALT elevations during MTX therapy in RA than recommended in current guidelines.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Homocysteine (Hcy) is associated with nonalcoholic fatty liver disease (NAFLD). orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) is involved in hepatic lipid metabolism. However, the potential role of NR4A1 in Hcy ‐associated NAFLD remains elusive. We aimed to elucidate the regulation of NR4A1 and its significance in Hcy‐induced NAFLD. Hcy induced steatosis and elevated the expression ofCD36 andFATP2 in HepG2 cells. Furthermore, Hcy enhanced p300 and decreased HDAC7 recruitment to theNR4A1 promoter, resulting in histone H3K27 hyperacetylation and NR4A1 upregulation. Moreover, NR4A1 depletion not only mimick...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Letter Source Type: research
Authors: Di Sessa A, Marzuillo P, Guarino S, Cirillo G, Miraglia Del Giudice E PMID: 31002001 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Authors: Tokodai K, Karadagi A, Kjaernet F, Romano A, Ericzon BG, Nowak G Abstract OBJECTIVES: Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS: We retrospectively examined 95 patients who had undergone LT for NASH or alcoholic liver disease (ALD) as a primary indication. We evaluated peritransplant characteristics and histological findings 1-year post LT amon...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
In this study, in seven distinct multi-generation families we found the causative gene for a rare Mendelian form of NAFLD. In a large Italian family with nine affected members with NAFLD and/or dyslipidemia, whole exome sequencing identified a heterozygous stop codon mutation in ABHD5.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
The DIAMOND ™ model is an inbred isogenic C57BL/6J x 129S1/SvImJ mouse that develops features of the human metabolic syndrome including obesity, the spectrum of non-alcoholic fatty liver disease (NAFLD), and diabetes. Approximately 10% also develop a spontaneous dermatitis after being placed on Western Diet ( WDSW). The aim of this study was to investigate histologic features of the observed cutaneous inflammation and to screen for alterations in hepatic gene expression that may impact the skin. Lesional and adjacent normal skin were harvested from mice on WDSW and age-matched negative controls on a norm al chow/norm...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
Publication date: Available online 19 April 2019Source: Redox BiologyAuthor(s): Liya Chen, Anna L. Lang, Gavin D. Poff, Wen-Xing Ding, Juliane I. BeierAbstractVinyl chloride (VC), an abundant environmental contaminant causes steatohepatitis at high levels, but is considered safe at lower (i.e., sub-OSHA) levels. However, we have previously shown that even lower VC levels exacerbate experimental nonalcoholic fatty liver disease (NAFLD) caused by high-fat diet (HFD). Mitochondrial oxidative injury and subsequent metabolic dysfunction appeared to play key roles in mediating this interaction. Mitochondrial aldehyde dehydrogena...
Source: Redox Biology - Category: Biology Source Type: research
More News: Clinical Trials | Fatty Liver Disease (FLD) | Health | Liver | Liver Disease | Urology & Nephrology