Autonomic Dysfunction in α-Synucleinopathies

Conclusions Dysautonomic symptoms frequently occuring in α-synucleinopathies comprise cardiovascular, gastrointestinal, urogenital and thermoregulatory disturbances. These symptoms reduce quality of life and worsen prognosis. The understanding of their pathophysiology, as well as the detection of α-synuclein deposition and autonomic dysfunction in the premotor stages of α-synucleinopathies may be key for identifying novel treatment targets and improving clinical outcomes. While causative treatment is not yet available, improvement of quality of life can be achieved by personalized symptomatic treatment regimens, which includes both and pharmacological and non-pharmacological strategies. Author Contributions JM-V: oversight of teamwork, literature search and review of articles, writing of abstract and parts 2, 3, and 4; JF-V: literature search and review of articles, writing of parts 1, 2, and 4; EB-V: review of articles, writing of parts 5 and 6; AS-O and B-MI: proofreading, expert advice on theoretical and clinical aspects; TS: proofreading, expert advice on theoretical and clinical aspects, identification of additional relevant papers. Funding We acknowledge support by the Open Access Publication Funds of the SLUB/TU Dresden. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. McCa...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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