Obesity-Related Genetic Variants and Hyperuricemia Risk in Chinese Men

Conclusion: The obesity-related SNP rs545854 was correlated with the serum uric acid level and risk of hyperuricemia in a male Chinese population. Therefore, men carrying this SNP could benefit from limiting their meat consumption to prevent hyperuricemia. These findings suggest an underlying genetic link between obesity and hyperuricemia worthy of further exploration. Introduction Serum uric acid (SUA) is a final product of the metabolic breakdown of purine oxidation (1). Since humans lack the gene for uricase that converts uric acid into a soluble form, the human uric acid level tends to be higher than that of other mammals that produce uricase (2). Indeed, an elevated SUA level was identified as the cause of gout in the early 1800s (3), and has since been associated with a wide range of health outcomes, including renal disorders, cardiovascular diseases, metabolic syndrome (MS), diabetes, and cancer (4–6). In addition, the high prevalence of hyperuricemia represents a great public health concern. The prevalence of hyperuricemia was reported at 21.0% in the total population, including 21.2% for men and 21.6% for women, in the USA (7). Moreover, the prevalence of hyperuricemia in Chinese men and women was recently reported at 19.4 and 7.9%, respectively (8). The varying levels of uric acid in human populations can be attributed to environmental factors such as diet, including dietary deficiency of uricase, and genetic factors (9). In addition, hyperuricemia is c...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
This study investigated B. cereus levels in fried rice meals in Milan (Italy) and the effect of a post contamination. Spores of three B. cereus (ATCC 14579, clinical isolate GPe2 and an isolate from fried rice R1) were inoculated in fried rice with ham, scrambled egg and peas, then stored at 10 °C and 15 °C for 5 days; the L2 component of haemolysin BL was quantified in the product. In a second trial, inoculated fried rice was submitted to microwave heating (2 min at 600 W) to investigate a possible decrease in bacterial loads. At 15 °C, spores germinated very quickly, followed by a fast growth espe...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
ConclusionsThe result showed that sampling region, fish status, fish species and sampling month were the main factors influencing infection rate. Regulations or guidelines are urgent in China for the control of Anisakis spp. infection in marine fish.
Source: Food Control - Category: Food Science Source Type: research
Authors: Kruthiventi SC, Kane GC, Sprung J, Weingarten TN, Warner ME Abstract Patients with pulmonary hypertension are at increased risk for postoperative pulmonary complications (PPCs). Herein, we review PPCs in pulmonary hypertension patients undergoing non-cardiac procedures under general anesthesia. The medical records of pulmonary hypertension patients who underwent surgery with general anesthesia between 2010 and 2017 were reviewed for PPCs. In addition we reviewed nursing-documented respiratory depressive episodes in the post-anesthesia care unit to assess the associations between these episodes and later PP...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Authors: Majumdar J, Mukhopadhyay S, Chandrakar A, Sengupta S, Ghosh B PMID: 31299856 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Srivastava A, Mathur AD PMID: 31299855 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Yasobant S, Mohanty S PMID: 31299854 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Dhungat JP PMID: 31299853 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
We report a case of maculopapular skin rash due to LEV with cross-sensitivity with CBZ which has not been reported till date. PMID: 31299852 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
We report a clinical case of DRESS syndrome with liver injury, evaluated with the RegiSCAR scoring system as a "definite case" possibly induced by carbamazepine in a patient. PMID: 31299851 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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