Obesity-Related Genetic Variants and Hyperuricemia Risk in Chinese Men
Conclusion: The obesity-related SNP rs545854 was correlated with the serum uric acid level and risk of hyperuricemia in a male Chinese population. Therefore, men carrying this SNP could benefit from limiting their meat consumption to prevent hyperuricemia. These findings suggest an underlying genetic link between obesity and hyperuricemia worthy of further exploration. Introduction Serum uric acid (SUA) is a final product of the metabolic breakdown of purine oxidation (1). Since humans lack the gene for uricase that converts uric acid into a soluble form, the human uric acid level tends to be higher than that of other mammals that produce uricase (2). Indeed, an elevated SUA level was identified as the cause of gout in the early 1800s (3), and has since been associated with a wide range of health outcomes, including renal disorders, cardiovascular diseases, metabolic syndrome (MS), diabetes, and cancer (4–6). In addition, the high prevalence of hyperuricemia represents a great public health concern. The prevalence of hyperuricemia was reported at 21.0% in the total population, including 21.2% for men and 21.6% for women, in the USA (7). Moreover, the prevalence of hyperuricemia in Chinese men and women was recently reported at 19.4 and 7.9%, respectively (8). The varying levels of uric acid in human populations can be attributed to environmental factors such as diet, including dietary deficiency of uricase, and genetic factors (9). In addition, hyperuricemia is c...
ConclusionFDG-PET/CT may steer the diagnosis (particularly thanks to a relatively high PPV and value of semiquantitative measurements), but cannot always classify vertebral bone lesions as malignant or benign with sufficient certainty. In these cases, biopsy and/or follow-up remain necessary to establish a final diagnosis.
ConclusionWe achieved promising results with this computer-aided diagnosis method that we tried to develop using convolutional neural networks based on transfer learning. This method can help clinicians for the diagnosis of hip osteoarthritis while interpreting plain pelvic radiographs, also provides assistance for a second objective interpretation. It may also reduce the need for advanced imaging methods in the diagnosis of hip osteoarthritis.
AbstractObjectiveTo investigate the associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with changes in knee cartilage composition and joint structure over 48 months, using magnetic resonance imaging (MRI) data from the Osteoarthritis Initiative (OAI).Materials and methodsA total of 1126 participants with right knee Kellgren-Lawrence (KL) score 0 –2 at baseline, no history of rheumatoid arthritis, blood pressure measurements at baseline, and cartilage T2 measurements at baseline and 48 months were selected from the OAI. Cartilage composition was assessed using MRI T2 measuremen...
Publication date: Available online 14 July 2020Source: Social Science &MedicineAuthor(s): Brian J. Hall, Lei Huang, Grace Yi, Carl Latkin
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Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Leonardo Franz, Lara Alessandrini, Giancarlo Ottaviano, Roberto di Carlo, Elena Fasanaro, Giulia Ramacciotti, Giacomo Contro, Gino Marioni
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