Upregulated VEGF and Robo4 correlate with the reduction of miR-15a in the development of diabetic retinopathy

ConclusionsVEGF and Robo4 were co-expressed in FVMs from PDR patients. In the early stages of DR, VEGF was upregulated and contributed to DR development, whereas, in the late stage of DR, VEGF and Robo4 worked together to aggravate DR progression. However, miR-15a could downregulate VEGF and Robo4 to ameliorate DR development.
Source: Endocrine - Category: Endocrinology Source Type: research