Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA.
Ethics Statement
This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital.
Informed Consent
The authors declare that written informed consent was obtained from the patient's parents for publication of this case report.
Author Contributions
GP, FdB, AM, and FL designed the study. GP, FdB, GC, DV, AntC, and IA cured the collection of the data. FdB, GC, IA, AndC, AM, GSC, TC, and FD-C interpreted and analyzed the data. GP, DV, FdB, and GC drafted the manuscript. FD-C performed immunohistochemistry analysis. EA performed molecular analysis. AM and FL critically revised the manuscript for intellectual content.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We thank the association Heal for the support.
References
1. De Graaf G, Buckley F, Skotko BG. Live births, natural losses, and elective terminations with Down syndrome in Massachuset...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Academia | Acute Leukemia | Acute Lymphoblastic Leukemia | Acute Myeloid Leukemia | Astrocytoma | Biology | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cardiology | Chemotherapy | Child Development | Childhood Cancer | Children | Corticosteroid Therapy | Down's Syndrome | Endocrinology | Epidemiology | Finland Health | Gastroenterology | Gastroschisis Repair | Genetics | Germ Cell Tumors | Germany Health | Glioma | Gorlin syndrome | Heart | Heart Transplant | Hematology | Hormones | Infectious Diseases | Israel Health | Italy Health | Japan Health | Laboratory Medicine | Leukemia | Medical Ethics | Medulloblastoma | Melanoma | Men | Methotrexate | Middle East Health | Molecular Biology | MRI Scan | Myeloproliferative Disorders | Neurology | Neurosurgery | OBGYN | Pathology | Pediatrics | Perinatology & Neonatology | Pilocytic Astrocytoma | Reproduction Medicine | Skin | Skin Cancer | Stem Cell Therapy | Stem Cells | Study | Thrombocytopenia | Thyroid | Thyroid Cancer | Toxicology | Translocation | Transplants | UK Health | Urology & Nephrology | USA Health