Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital. Informed Consent The authors declare that written informed consent was obtained from the patient's parents for publication of this case report. Author Contributions GP, FdB, AM, and FL designed the study. GP, FdB, GC, DV, AntC, and IA cured the collection of the data. FdB, GC, IA, AndC, AM, GSC, TC, and FD-C interpreted and analyzed the data. GP, DV, FdB, and GC drafted the manuscript. FD-C performed immunohistochemistry analysis. EA performed molecular analysis. AM and FL critically revised the manuscript for intellectual content. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank the association Heal for the support. References 1. De Graaf G, Buckley F, Skotko BG. Live births, natural losses, and elective terminations with Down syndrome in Massachusetts...
Publication date: Available online 2 July 2020Source: International Journal of Clinical and Health PsychologyAuthor(s): Caterina Calderon, Urbano Lorenzo-Seva, Pere Joan Ferrando, David Gómez-Sánchez, Estrella Ferreira, Laura Ciria-Suarez, Marta Oporto-Alonso, Marina Fernández-Andujar, Paula Jiménez-Fonseca
Authors: Cresi F, Cester EA, Salvatore S, De Rose DU, Ripepi A, Magistà AM, Fontana C, Maggiora E, Coscia A, Francavilla R, Cristofori F Abstract Background/Aims: Combined multichannel intraluminal impedance and pH monitoring (MII/pH) is considered the most accurate test to detect gastroesophageal reflux (GER), however lacking reference values. We aim to determine reference values for the pediatric population and to correlate these values with age and postprandial/fasting period. Methods: We evaluated MII/pH traces from patients (newborns, infants, and children) admitted to 3 Italian hospitals and who un...
Publication date: Available online 1 July 2020Source: Joint Bone SpineAuthor(s): Shamma Ahmad Al Nokhatha, Robert Harrington, Richard Conway
Publication date: Available online 2 July 2020Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Douglas Matsunaga, Basil K. Williams, Komal B. Desai, Carol L. Shields
Publication date: July–August 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 5Author(s): Levent Mutlu, Wafa Khadraoui, Tarek Khader, Gulden Menderes
Publication date: July–August 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 5Author(s): Víctor Lago, Pilar Bello, Luis Matute, Pablo Padilla-Iserte, Tiermes Marina, Marc Agudelo, Santiago Domingo
Publication date: Available online 2 July 2020Source: Gynecologic Oncology ReportsAuthor(s): Ricardo Pedrini Cruz, Gustavo Peretti Rodini, Margarete Duarte da Rosa, Vinicius Duarte Cabral, Eduardo Cambruzzi, Gabriella Ferrandina, Reitan Ribeiro
Publication date: Available online 2 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Laura D’Erasmo, Daniela Commodari, Alessia Di Costanzo, Ilenia Minicocci, Luca Polito, Fabrizio Ceci, Anna Montali, Marianna Maranghi, Marcello Arca
D, Henriques JAP Abstract Cell cycle alterations are among the principle hallmarks of cancer. Consequently, the study of cell cycle regulators has emerged as an important topic in cancer research, particularly in relation to environmental exposure. Particulate matter and coal dust around coal mines have the potential to induce cell cycle alterations. Therefore, in the present study, we performed chemical analyses to identify the main compounds present in two mineral coal samples from Colombian mines and performed systems chemo-biology analysis to elucidate the interactions between these chemical compounds and prot...
Authors: Deng Y, Chen C, Xiao Z, Huang X, Xu J Abstract The novel curcumin analog C086, previously identified as an oral novel heat shock protein 90 (Hsp90) inhibitor, was found to exhibit anti-hepatoma activity in vitro and in vivo. However, owing to its limited aqueous solubility, the usage of C086 in the clinical application was restricted. This research focused on the increase of the aqueous solubility and bioavailability of C086 via a solid dispersion preparation to improve its accumulation in the liver, which accordingly enhanced anti-hepatoma activity. C086-solid dispersion (C086-SD) was successful...
More News: Academia | Acute Leukemia | Acute Lymphoblastic Leukemia | Acute Myeloid Leukemia | Astrocytoma | Biology | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cardiology | Chemotherapy | Child Development | Childhood Cancer | Children | Corticosteroid Therapy | Down's Syndrome | Endocrinology | Epidemiology | Finland Health | Gastroenterology | Gastroschisis Repair | Genetics | Germ Cell Tumors | Germany Health | Glioma | Gorlin syndrome | Heart | Heart Transplant | Hematology | Hormones | Infectious Diseases | Israel Health | Italy Health | Japan Health | Laboratory Medicine | Leukemia | Medical Ethics | Medulloblastoma | Melanoma | Men | Methotrexate | Middle East Health | Molecular Biology | MRI Scan | Myeloproliferative Disorders | Neurology | Neurosurgery | OBGYN | Pathology | Pediatrics | Perinatology & Neonatology | Pilocytic Astrocytoma | Reproduction Medicine | Skin | Skin Cancer | Stem Cell Therapy | Stem Cells | Study | Thrombocytopenia | Thyroid | Thyroid Cancer | Toxicology | Translocation | Transplants | UK Health | Urology & Nephrology | USA Health