Basket Trials for Intractable Cancer
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the experts from Refractory Malignancy Society of Chinese Medical Education Association for the consultation. References 1. Tao JJ, Schram AM, Hyman DM. Basket studies: redefining clinical trials in the era of genome-driven oncology. Annu Rev Med. (2018) 69:319–31. doi: 10.1146/annurev-med-062016-050343 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Mcneil C. NCI-MATCH launch highlights new trial design in precision-medicine era. J Natl Cancer Inst. (2015) 107:djv193. doi: 10.1093/jnci/djv193 PubMed Abstract | CrossRef Full Text | Google Scholar 3. Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. (2011) 364:2507–16. doi: 10.1056/NEJMoa1103782 PubMed Abstract | CrossRef Full Text | Google Scholar 4. Hainsworth JD...
This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. 30% had distal femoral metastases in addition to other areas of involvement. 7% of patients with femoral metastases had only distal femur disease. 6 patients had distal pathologic fractures. Exclusion of the distal femur during PET/CT may result in a missed or delayed diagnosis that could contribute to the develo...
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In conclusion, our findings provide d the direct evidences and the crucial role of NPY in cartilage homeostasis.This article is protected by copyright. All rights reserved.
Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
To compare pre- and postoperative MRI-based anatomical findings following native tissue prolapse repair.
To assess factors and charges associated with hospital revisits following benign hysterectomy in the United States.
To compare changes in body image among women with uterovaginal prolapse undergoing vaginal mesh hysteropexy (mesh hysteropexy) or vaginal hysterectomy with uterosacral ligament suspension (hysterectomy).
The use of power morcellation has been restricted in many centers due to concerns for inadvertent spread of an undiagnosed leiomyosarcoma. Our institution implemented a preoperative protocol to avoid power morcellation in high risk cases. In this retrospective cohort study, we report the impact of this protocol on institutional surgical practice patterns, and the influence of MRI and LDH results on surgical route.
Our objective was to evaluate the utility of concomitant injection of a human plasma derived exosome product (Purified Exosome Product; PEP) during surgical repair of anal sphincter injuries in a porcine model of obstetric anal sphincter injury. We aimed to evaluate the impact on anorectal manometry parameters and wound healing.
To compare the incidence of perioperative adverse events in women undergoing vaginal prolapse repair with uterine preservation (hysteropexy) versus concurrent hysterectomy.
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