Clinical Efficacy of CyberKnife Radiosurgery for Adult Brainstem Glioma: 10 Years Experience at Tianjin CyberKnife Center and Review of the Literature

Conclusion: The efficacy of brainstem gliomas—treated with CyberKnife is efficacious with mild toxicity. Introduction Brainstem gliomas (BSGs) account for 5–15% of brain tumors and more likely happen in children (1). BSGs constitute at least 20% of childhood brain neoplasms (2), and the peak age is 7–9 years. In contrast, BSGs is rare in the adult population and account for only 1.5–2.5% of brain glioma, with a peak age of 40–70 years (1). Diffuse intrinsic pontine glioma(DIPG) was the most common type of BSG is that could invade the whole brainstem including midbrain, pons as well as medulla, thus surgery resection has the most challenges and may not be taken as the appropriate approach. In the meanwhile, even some progress have been made recently in genomic profile of DIPG, the prognosis still remains poor, with an average survival of 10–12 months (3). Unlike children, there is a much more broad pathology spectrum in adult brainstem glioma, which squint toward be more radiographically and clinically diversified. The study done by Babu et al. reported that diffuse intrinsic low grade BSGs in adult are the main subgroup of BSGs with a poor prognosis in comparing with malignant BSGs (4). The main function for brainstem which is composed of brainstem nuclei and white matter tracts is to maintain basic life function such as respiratory as well as heart beat ect, thus, to resect brainstem neoplasm becomes challenging. So does the minimum...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Conclusions: The bibliometric analysis allowed to objectively record the productivity and visibility of the Regional System for Vaccines for Streptococcus pneumoniae in the Region. PMID: 32774349 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Publication date: Available online 11 August 2020Source: Journal of Oral BiosciencesAuthor(s): Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research
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Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Silvia Malavasi, Alessandro Bevilacqua, Giampaolo Gavelli, Domenico Barone
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Shiyu Sun, Wufeng Xue, Yongjin Zhou
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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Publication date: July 2020Source: Biomedical and Environmental Sciences, Volume 33, Issue 7Author(s): Fei Ran WEI, Li Lin XIONG, Wei LI, Xue Rong WANG, Xin HONG, Bao An CHEN
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
CONCLUSION: Self-reported health service usage after mammographic screening is higher in women who have been notified they have dense breasts. SO WHAT?: There is growing pressure for screening programs in Australia and internationally to routinely measure and report breast density to participants. Results from this study can inform screening programs of the likely impact of breast density notification on health service usage. While more information is needed to fill knowledge gaps in recommended action for women with dense breasts, the greatest risks to women arise from not being screened. Hence, health promotion practitio...
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
NF-κB transcription factors, driven by the IRAK/IKK cascade, confer treatment resistance in pancreatic ductal adenocarcinoma (PDAC), a cancer characterized by near-universal KRAS mutation. Through reverse-phase protein array and RNA sequencing we discovered that IRAK4 also contributes substantially to MAPK activation in KRAS-mutant PDAC. IRAK4 ablation completely blocked RAS-induced transformation of human and murine cells. Mechanistically, expression of mutant KRAS stimulated an inflammatory, autocrine IL-1β signaling loop that activated IRAK4 and the MAPK pathway. Downstream of IRAK4, we uncovered TPL2 (also k...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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