Hyperammonemia after capecitabine associated with occult impairment of the urea cycle

ConclusionsCapecitabine and 5 ‐fluorouracil inhibit pyrimidine biosynthesis, decreasing ammonia utilization. These drugs can induce hyperammonemia in susceptible individuals. The risk factors of hyperammonemia, gene mutations and liver dysfunction, are not rare. Diagnosis will trigger appropriate treatment and ameliorate brain toxicity.

Source: Cancer Medicine - April 10, 2019 Category: Cancer & Oncology Authors: Gilbert Chu, Julia Salzman Tags: ORIGINAL RESEARCH Source Type: research