The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not restricted to directly increase phagocytosis. PTX3 can be used as a sensor by complement to rapidly recognize microbial patterns and enhance its activation and its antimicrobial activity. Once bound, PTX3 recruits the complement component C1q and activate the classical pathway of the complement cascade, leading to C3 deposition on apoptotic cells (32). In contrast, the interaction between PTX3 and C1q in the fluid phase prevents complement deposition onto apoptotic cells and their clearance by dendritic cells (33). PTX3 also interacts and activates the lectin pathway of complement. Indeed, Ma et al. demonstrated that PTX3 bound on A. fumigatus conidia interacts with ficolin-2 and leads to an increase of complement deposition on A. fumigatus (34). Later on, this group showed that the interaction of PTX3 with ficolin-1 on the cell surface of apoptotic cells l...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

CONCLUSION: The results of our study may offer useful evidence for future development of female-specific prevention and public health intervention programs in aboriginal communities to reduce the burden of ACO. PMID: 31106621 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
CONCLUSIONS: Anti-IL-17a treatment was associated with a nearly 3-fold higher risk of IBD in CID patients. Treatment decisions for patients with CIDs should take into account the risk of developing of IBD. PMID: 31106607 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Marinho PM, Salomon TB, Andrade AS, Behling CS, Putti JS, Benfato MS, Schäfer Hackenhaar F Abstract Menopause occurs as consequence of ovarian senescence that leads to a drop of oestrogen hormone. The decreased oestrogen levels combined with the impairment of the redox system may contribute to the increased risk of postmenopausal cardiovascular disease. Supplementation with antioxidants may be an alternative to reduce cardiovascular risk. The study evaluated the effect of dietary supplementation with docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and alpha-lipoic acid (LA) for a period of 16&...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Shigematsu K, Iwashita K, Mimata R, Owaki R, Totoki T, Gohara A, Okawa J, Higashi M, Yamaura K Abstract This retrospective study was aimed to investigate the association between preoperative left ventricular (LV) cardiac function and the incidence of postoperative pulmonary edema (PE) in patients undergoing carotid endarterectomy (CEA). Most patients undergoing CEA for carotid artery stenosis have concomitant heart diseases, leading to hemodynamic instability that can cause postoperative cardiac complications such as cardiac heart failure. LV diastolic function has recently been recognized as an independen...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Hearthside Food Solutions of Woodridge, IL is voluntarily recalling 7-Eleven ‘The Italian Job’ sandwiches, which have an incorrect information panel label that does not declare eggs as an allergen. Persons who have an allergy or severe sensitivity to eggs run the risk of serious or life-threatening
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Chukar Cherries of Prosser, WA expands a recall on Ultra Dark Chocolate product because it may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products.
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Authors: Reis MO, Souza FR, Albuquerque AS, Monteiro F, Oliveira LFDS, Raymundo DL, Wouters F, Wouters ATB, Peconick AP, Varaschin MS Abstract Trypanosomiasis is caused by a pathogenic protozoan of the genus Trypanosoma, being Trypanosoma vivax the most important agent for cattle. The aim of the present study was to demonstrate the expansion of T. vivax infection in different mesoregions of Minas Gerais, Brazil, and describe the clinicopathological findings of trypanosomiasis in cattle. The diagnosis was based on visualization of the parasite in blood smears and DNA detection of T. vivax in the blood of live cows a...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Kim J, Shin MY, Park SJ Abstract To identify the component(s) involved in cell cycle control in the protozoan Giardia lamblia, cells arrested at the G1/S- or G2-phase by treatment with nocodazole and aphidicolin were prepared from the synchronized cell cultures. RNA-sequencing analysis of the 2 stages of Giardia cell cycle identified several cell cycle genes that were up-regulated at the G2-phase. Transcriptome analysis of cells in 2 distinct cell cycle stages of G. lamblia confirmed previously reported components of cell cycle (PcnA, cyclin B, and CDK) and identified additional cell cycle components (NEKs...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Shin SP, Jin CN, Sohn HC, Lee J Abstract Sinuolinea capsularis Davis, 1917 is myxosporean that infect the urinary system of the host fish. Insufficient morphological and molecular data of S. capsularis exits, and it is therefore difficult to make an accurate identification of the parasite. We tried a series of morphological and molecular analysis to identify an myxosporean isolated from urinary bladder of cultured olive flounder, Paralichthys olivaceus, from Jeju island in the Republic of Korea. Some of them were observed under a light microscope and SEM, and remain samples were used molecular and phylogen...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Yang H, Zhong JT, Zhou SH, Han HM Abstract The Warburg effect plays an important role in the proliferation and invasion of malignant tumors. Glucose transporter 1 and hexokinase II are two key energy transporters involved in mediating the Warburg effect. This review will analyze the mechanisms of these two markers in their effects on the biological behavior of head and neck cancer. PMID: 31105886 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
More News: Academies | Acute Leukemia | African Health | Allergy & Immunology | Antibiotic Therapy | Aspergillosis | Aspergillus | Bone Marrow Aspiration and Biopsy | Brain | Breast Conservation Surgery | Cancer | Cancer & Oncology | Candida | Cardiogenic Shock | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | Chemotherapy | Child Development | Children | Chronic Kidney Disease | Chronic Leukemia | Chronic Obstructive Pulmonary | Cryptococcosis | Cystic Fibrosis | Cytomegalovirus | Dengue Fever | Dysentery | Emergency Medicine | Epithelial Cancer | Fungal Infections | Gastroenteritis | Gastroschisis Repair | Genetics | Grants | H3N2 | Heart | Heart Attack | Heart Failure | Heart Transplant | Infectious Diseases | Inflammatory Bowel Disease | Influenza | Intensive Care | Italy Health | Kidney Transplant | Kidney Transplantation | Leukemia | Liver | Liver Transplant | Lung Cancer | Lung Transplant | Men | Meningitis | Microbiology | Milk | Molecular Biology | Neurology | Neurosurgery | Pediatrics | Perinatology & Neonatology | PET Scan | Physiology | Pneumonia | Pregnancy | Pyelonephritis | Reproduction Medicine | Respiratory Medicine | Septic Shock | Staphylococcus Aureus | Stem Cell Therapy | Stem Cells | Study | Sweden Health | Thyroid | Thyroid Cancer | Training | Transplant Surgery | Transplants | Tuberculosis | UK Health | Universities & Medical Training | Urinary Tract Infections | Urology & Nephrology | Vitamin D | Vitamin D Deficiency | Vitamins