Distinct Functions of Bombyx mori Peptidoglycan Recognition Protein 2 in Immune Responses to Bacteria and Viruses

In conclusion, we cloned two forms of BmPGRP2 generated from different TIS and characterized their distinct functions in the host immune response to pathogens (Figure 7). Our findings indicate that BmPGRP2-2 does not function in canonical immune signaling pathways and PGRP2 is not only involved in host immune defense against invading pathogens, but is also used by viruses to evade host antiviral mechanisms. Author Contributions LJ and QX designed research. LJ, HG, TC, WY, and QX analyzed data. LJ, WL, YD, QS, BW, YW, and EX performed experiments. LJ and QX wrote the manuscript. Funding This work was funded by the National Natural Science Foundation of China (No. 31501875, No. 31802014), the Natural Science Foundation of Chongqing, China (cstc2018jcyjAX0211, cstc2018jcyjAX0487, cstc2016jcyjA0524), and Chongqing Postdoctoral Science Foundation (XmT2018006). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank Dr. Xiaofeng Wu for gifting the BmNPV-GFP virus, Takahiro Kusakabe for gifting the BmN4-SID1 cells, Dr. Pingzhen Xu, Dr. Qiong Yang, and Mrs. Yang Xiao for the help in experiment, Dr. Jun Duan and Dr. Yuqian Wu for the help in RNA-seq data analysis. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research