Gated single-photon emission computed tomography myocardial perfusion imaging is superior to computed tomography attenuation correction in discriminating myocardial infarction from attenuation artifacts in men and right coronary artery disease

Background In single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) studies, attenuation artifacts frequently cause false positives, which can be partially overcome by computed tomography attenuation correction (CT-AC) or gated acquisition [gated myocardial perfusion imaging (GMPI)]. The purpose of this study is to evaluate their relative diagnostic performances for coronary artery disease (CAD). Patients and methods We enrolled 181 patients who underwent gated SPECT with CT-AC in this study. Two observers who were blinded to the clinical data interpreted the GMPI and CT-AC images. Coronary angiography was considered as the reference standard. The diagnostic efficacy was evaluated based on sex, BMI, and individual coronary arteries. Results The diagnostic accuracy of GMPI was higher than that of nonattenuation correction overall, as well as for men, overweight individuals, and right CAD (P0.05). For diagnosing right CAD, GMPI had a higher diagnostic efficacy (AUC: 0.733 vs. 0.596, P
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research