Photochemical /Photocytotoxicity studies of new tetrapyrrolic structures as potential candidates for cancer theranostics.

Photochemical /Photocytotoxicity studies of new tetrapyrrolic structures as potential candidates for cancer theranostics. Curr Drug Discov Technol. 2019 Apr 10;: Authors: Ferreira LFV, Machado IF, Gama A, Socoteanu RP, Boscencu R, Manda G, Calhelha RC, Ferreira ICFR Abstract Detailed photochemical and photocytotoxicity studies of two new porphyrins: 5,10,15,20-meso-tetrakis-(4-acetoxy-3-methoxyphenyl) porphyrin (P2.1) and 5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrin (P2.2) are reported, as potential candidates for theranostics. For powdered samples of P2.1 and P2.2 adsorbed onto a powdered biocompatible substrate, polyethylene glycol (PEG), a concentration study was performed, correlating the fluorescence emission intensity with sample absorption to determine the useful concentration range for photodynamic therapy of cancer (PDT) in which aggregation does not occur. Fluorescence emission quantum yields and lifetimes were also determined for all samples under study, because it is well known that these parameters for aggregated porphyrins are lower than those obtained for the monomeric forms of the photosensitizers and the same occurs with the singlet oxygen quantum yields, therefore decreasing the PDT action. Cytotoxicity studies were performed in dark and illuminated conditions, using four different human tumor cell lines and one non-tumor primary cell culture. The two porphyrins evidenced very goo...
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research