Hybrid design of isonicotinic acid hydrazide derivatives: machine learning studies, synthesis and biological evaluation of their anti-tuberculosis activity.

CONCLUSION: The newly identified compounds may represent a starting point for further development of therapies against Mtb. The developed models are available online at OCHEM http://ochem.eu/article/111066 and can be used to virtually screen for potential compounds with anti-TB activity. PMID: 30973110 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30973110?dopt=Abstract

Source: Current Drug Discovery Technologies - April 10, 2019 Category: Drugs & Pharmacology Authors: Kovalishyn V, Hodyna D, Sinenko VO, Blagodatny V, Semenyuta I, Slivchuk SR, Brovarets V, Poda G, Metelytsia L Tags: Curr Drug Discov Technol Source Type: research